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Titolo:
Biochemical changes in the efferent lymph plasma after oxazolone stimulation
Autore:
West, CA; Fischer, GA; Young, AJ; He, CF; Su, M; Mentzer, SJ;
Indirizzi:
Harvard Univ, Brigham & Womens Hosp, Sch Med,Lab Immunophysiol, Dana Farber Canc Inst,Surg Res Labs, Boston, MA 02115 USA Harvard Univ Boston MA USA02115 Inst,Surg Res Labs, Boston, MA 02115 USA
Titolo Testata:
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
fascicolo: 1, volume: 26, anno: 2002,
pagine: 111 - 119
SICI:
0145-305X(200201)26:1<111:BCITEL>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEHYDROGENASE LDH ISOENZYMES; NODE CORTEX; CHOLESTEROL; SERUM; MACROPHAGES; LYMPHOCYTES; CULTURE; CELLS; INVOLVEMENT; ACTIVATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Mentzer, SJ Harvard Univ, Brigham & Womens Hosp, Sch Med,Lab Immunophysiol, Dana Farber Canc Inst,Surg Res Labs, 75 Francis St, Boston, MA 02115 USA Harvard Univ 75 Francis St Boston MA USA 02115 n, MA 02115 USA
Citazione:
C.A. West et al., "Biochemical changes in the efferent lymph plasma after oxazolone stimulation", DEV COMP IM, 26(1), 2002, pp. 111-119

Abstract

The lymph node is a specialized microenvironment for the regulation of immune responses. The reticular network of the lymph node provides a structurethat facilitates not only intercellular interactions, but the intranodal flow of lymph fluid. To assess biochemical changes in the nodal lymph plasmaafter antigen stimulation, prescapular lymph nodes in sheep were stimulated with the epicutaneous antigen oxazolone. The efferent lymph from both antigen-stimulated and contralateral control prescapular lymph nodes was continuously monitored for more than 120 h. The oxazolone-stimulated lymph plasma was associated with a selective increase in cholesterol content during the 'recruitment' phase of lymph node enlargement. The peak in cholesterol was followed closely by a significant increase in lymph plasma LDH concentration. In contrast, there was no significant difference between oxazolone-stimulated and control lymph plasma in the concentration of triglycerides, albumin, alkaline phosphatase, and alanine transferase. These selective biochemical changes in the efferent lymph appeared to reflect the dynamics of lymphocyte activation within the lymph node as well as provide a practical measure of the lymph node response to antigen stimulation. (C) 2001 Elsevier Science Ltd. All rights reserved.

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Documento generato il 29/03/20 alle ore 14:22:44