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Titolo:
The effects of thymulin on macrophage responsiveness to interferon-gamma
Autore:
Orringer, DA; Staeheli, P; Marsh, JA;
Indirizzi:
Cornell Univ, Coll Vet Med, Dept Microbiol & Immunol, Ithaca, NY 14853 USACornell Univ Ithaca NY USA 14853 icrobiol & Immunol, Ithaca, NY 14853 USA Univ Freiburg, Inst Med Microbiol & Hyg, Abt Virol, D-79008 Freiburg, Germany Univ Freiburg Freiburg Germany D-79008 Virol, D-79008 Freiburg, Germany
Titolo Testata:
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
fascicolo: 1, volume: 26, anno: 2002,
pagine: 95 - 102
SICI:
0145-305X(200201)26:1<95:TEOTOM>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
THYMIC-FACTOR FTS; IFN-GAMMA; TRIIODOTHYRONINE; EXPRESSION; RECEPTOR; INTERLEUKIN-2; CHICKENS; CELLS; ZINC;
Keywords:
chickens; macrophages; abdominal exudate cells; interferon-gamma; nitric oxide; HD-11;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Marsh, JA Cornell Univ, Coll Vet Med, Dept Microbiol & Immunol, C5-103 VMC, Ithaca, NY 14853 USA Cornell Univ C5-103 VMC Ithaca NY USA 14853 Ithaca, NY 14853 USA
Citazione:
D.A. Orringer et al., "The effects of thymulin on macrophage responsiveness to interferon-gamma", DEV COMP IM, 26(1), 2002, pp. 95-102

Abstract

The effect of in vivo and in vitro thymulin treatments on macrophage responsiveness to interferon-gamma was evaluated in chickens. Seven-week-old chickens were treated with 0, 1, 10, or 100 ng thymulin per 100 g body weight. Abdominal exudate cells (AEC), a source of macrophages, were hat-vested and cultured in the presence of graded levels of recombinant chicken interferon-gamma (ChIFN-gamma). Responsiveness to ChIFN-gamma was determined by measuring the induction of nitric oxide production. One and 2-day thymulin treatment at 10 and 100 ng per 100 g body weight doses significantly increasedresponsiveness to ChIFN-gamma while 1 mg per 100 g body weight had no effect. Other experiments compared the effect of thymulin treatments in CornellK strain chickens, having normal serum thymulin levels with sex-linked dwarf (SLD) chickens which are deficient in serum thymulin. The dose of thymulin treatment required to significantly increase responsiveness to ChIFN-gamma differed between strains. Finally, the effect of direct in vitro thymulin treatments on macrophage, responsiveness to ChIFN-gamma was evaluated. There were no significant increases in responsiveness to ChIFN-gamma between treatment groups within the macrophage cell line, HD-11, when cultured in the presence of 0-200 pg thymulin/ml. These data suggest that the effect of thymulin on AEC responsiveness to ChIFN-gamma is indirectly mediated. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 13:09:24