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Titolo:
Cloning and characterization of a chicken platelet-derived growth factor B-chain cDNA
Autore:
Horiuchi, H; Inoue, T; Furusawa, S; Matsuda, H;
Indirizzi:
Hiroshima Univ, Fac Appl Biol Sci, Dept Immunobiol, Higashihiroshima 7398528, Japan Hiroshima Univ Higashihiroshima Japan 7398528 hihiroshima 7398528, Japan
Titolo Testata:
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
fascicolo: 1, volume: 26, anno: 2002,
pagine: 73 - 83
SICI:
0145-305X(200201)26:1<73:CACOAC>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
SIMIAN SARCOMA-VIRUS; FACTOR PDGF; SELECTIVE EXPRESSION; RECEPTOR-BINDING; ALPHA RECEPTOR; CELL LINES; ESTABLISHMENT; SEQUENCE; REGION; DIFFERENTIATION;
Keywords:
chicken; PDGF B-chain; platelets; thrombocytes;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Horiuchi, H Hiroshima Univ, Fac Appl Biol Sci, Dept Immunobiol, Higashihiroshima 7398528, Japan Hiroshima Univ Higashihiroshima Japan 7398528 7398528, Japan
Citazione:
H. Horiuchi et al., "Cloning and characterization of a chicken platelet-derived growth factor B-chain cDNA", DEV COMP IM, 26(1), 2002, pp. 73-83

Abstract

Avian thrombocytes are nucleated blood cells homologous in function to mammalian platelets. In the present study, we obtained a cDNA from chicken thrombocyte polyadenylated RNA [Poly(A) + RNA], which coded for the chicken PDGF-B chain. The sequence was 1083-bp long and had an open reading frame (ORF) of 753-bp. At the amino acid level, the predicted mature protein showed 69% homology with the processed coding region of human PDGF-B. Reverse transcriptase-polymerase chain reaction (RT-PCR) analysis showed that PDGF-B mRNA was expressed at high levels in thrombocytes and in the lung. The expression of PDGF-B chain mRNA in thrombocytes reached its maximum level 12 It following type I collagen treatment. These results suggest that chicken PDGF-B chain may play an important role in the vascular system and in healing wounded tissue. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 20:37:41