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Titolo:
An invertebrate defense molecule activates membrane conductance in mammalian cells by means of its lectin-like domain
Autore:
Bloc, A; Lucas, R; Van Dijck, E; Bilej, M; Dunant, Y; De Baetselier, P; Beschin, A;
Indirizzi:
Ctr Med Univ Geneva, Fac Med, Dept Pharmacol, Geneva 4, Switzerland Ctr Med Univ Geneva Geneva Switzerland 4 harmacol, Geneva 4, Switzerland Univ Konstanz, Dept Biochem Pharmacol, D-78457 Constance, Germany Univ Konstanz Constance Germany D-78457 acol, D-78457 Constance, Germany Free Univ Brussels, Flemish Interuniv Inst Biotechnol, Dept Immunol Parasitol & Ultrastruct, B-1640 Rhode St Genese, Belgium Free Univ Brussels Rhode St Genese Belgium B-1640 ode St Genese, Belgium Acad Sci Czech Republ, Inst Microbiol, Dept Immunol, Prague 4, Czech Republic Acad Sci Czech Republ Prague Czech Republic 4 , Prague 4, Czech Republic
Titolo Testata:
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
fascicolo: 1, volume: 26, anno: 2002,
pagine: 35 - 43
SICI:
0145-305X(200201)26:1<35:AIDMAM>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; MICROVASCULAR ENDOTHELIAL-CELLS; FACTOR-ALPHA; EISENIA-FOETIDA; TNF RECEPTORS; BINDING; IDENTIFICATION; MACROPHAGES; EARTHWORMS; PROTEIN;
Keywords:
CCF-1; TNF; amiloride-sensitive conductance; innate immunity; lectin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Lucas, R Ctr Med Univ Geneva, Fac Med, Dept Pharmacol, Geneva 4, Switzerland Ctr Med Univ Geneva Geneva Switzerland 4 Geneva 4, Switzerland
Citazione:
A. Bloc et al., "An invertebrate defense molecule activates membrane conductance in mammalian cells by means of its lectin-like domain", DEV COMP IM, 26(1), 2002, pp. 35-43

Abstract

The invertebrate defense molecule Coelomic Cytolytic Factor-1 (CCF-1) and the mammalian cytokine Tumor Necrosis Factor (TNF) share a similar lectin-like domain that, upon interaction with specific sugars, causes lysis of African trypanosomes. In contrast to TNF, CCF- I does not require an acidification of a lysosomal compartment for this activity. Moreover, we could demonstrate using the whole cell patch clamp technique that both TNF and CCF-1 activate amiloride-sensitive channels in mammalian cells, in a TNF receptor-independent way, but, unlike TNF, CCF-1 does not require acidic conditions for this activity. These data confirm the functional analogies of an invertebrate defense molecule and a mammalian cytokine, based on a similar lectin-like interaction. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 11:30:20