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Titolo:
Regulation of CNS and motor axon guidance in Drosophila by the receptor tyrosine phosphatase DPTP52F
Autore:
Schindelholz, B; Knirr, M; Warrior, R; Zinn, K;
Indirizzi:
CALTECH, Div Biol, Pasadena, CA 91125 USA CALTECH Pasadena CA USA 91125CALTECH, Div Biol, Pasadena, CA 91125 USA Univ So Calif, Dept Biol, Los Angeles, CA 90089 USA Univ So Calif Los Angeles CA USA 90089 pt Biol, Los Angeles, CA 90089 USA
Titolo Testata:
DEVELOPMENT
fascicolo: 21, volume: 128, anno: 2001,
pagine: 4371 - 4382
SICI:
0950-1991(200111)128:21<4371:ROCAMA>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROWTH CONE GUIDANCE; NERVOUS-SYSTEM AXONS; CAENORHABDITIS-ELEGANS; PIONEER NEURONS; PROTEIN-KINASES; EMBRYONIC CNS; GENE; MELANOGASTER; INTERFERENCE; SUBSTRATE;
Keywords:
receptor tyrosine phosphatase; PTP; Drosophila; neural development; axon guidance; neuromuscular system; genomics; motor axon; RNAi;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Zinn, K CALTECH, Div Biol, Pasadena, CA 91125 USA CALTECH Pasadena CA USA91125 H, Div Biol, Pasadena, CA 91125 USA
Citazione:
B. Schindelholz et al., "Regulation of CNS and motor axon guidance in Drosophila by the receptor tyrosine phosphatase DPTP52F", DEVELOPMENT, 128(21), 2001, pp. 4371-4382

Abstract

Receptor-linked protein tyrosine phosphatases (RPTPs) regulate axon guidance and synaptogenesis in Drosophila embryos and larvae. We describe DPTP52F, the sixth RPTP to be discovered in Drosophila. Our genomic analysis indicates that there are likely to be no additional RPTPs encoded in the fly genome. Five of the six Drosophila RPTPs have C. elegans counterparts, and three of the six are also orthologous to human, RPTP subfamilies. DPTP52F, however, has no clear orthologs in other organisms. The DPTP52F extracellular domain contains five fibronectin type III repeats and it has a single phosphatase domain. DPTP52F is selectively expressed in the CNS of late embryos,as are DPTP10D, DLAR, DPTP69D and DPTP99A. To define developmental roles of DPTP52F, we used RNA interference (RNAi)-induced phenotypes as a guide toidentify Ptp52F alleles among a collection of EMS-induced lethal mutations. Ptp52F single mutant embryos have axon guidance phenotypes that affect CNS longitudinal tracts. This phenotype is suppressed in Dlar Ptp52F double mutants, indicating that DPTP52F and DLAR interact competitively in regulating CNS axon guidance decisions. Ptp52F single mutations also cause motor axon phenotypes that selectively affect the SNa nerve. DPTP52F, DPTP10D and DPTP69D have partially redundant roles in regulation of guidance decisions made by axons within the ISN and ISNb motor nerves.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/07/20 alle ore 18:19:40