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Titolo:
Understanding the neurobiology of suicidal behavior
Autore:
Kamali, M; Oquendo, MA; Mann, JJ;
Indirizzi:
Columbia Univ, Coll Phys & Surg, Dept Neurosci, New York, NY 10032 USA Columbia Univ New York NY USA 10032 Dept Neurosci, New York, NY 10032 USA New York State Psychiat Inst & Hosp, New York, NY 10032 USA New York StatePsychiat Inst & Hosp New York NY USA 10032 k, NY 10032 USA
Titolo Testata:
DEPRESSION AND ANXIETY
fascicolo: 3, volume: 14, anno: 2001,
pagine: 164 - 176
SICI:
1091-4269(2001)14:3<164:UTNOSB>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
ADRENERGIC-RECEPTOR BINDING; HUMAN BRAIN POSTMORTEM; REGIONALLY SELECTIVE INCREASES; CENTRAL SEROTONERGIC FUNCTION; TRITIATED IMIPRAMINE BINDING; MAJOR DEPRESSIVE DISORDER; LOW SERUM-CHOLESTEROL; 5-HT UPTAKE SITES; FRONTAL-CORTEX; CEREBROSPINAL-FLUID;
Keywords:
suicide; serotonin; rapbe nuclei; prefrontal cortex;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Citazioni:
155
Recensione:
Indirizzi per estratti:
Indirizzo: Oquendo, MA Columbia Univ, Coll Phys & Surg, Dept Neurosci, 1051 RiversideDr, New York, NY 10032 USA Columbia Univ 1051 Riverside Dr New York NY USA10032 0032 USA
Citazione:
M. Kamali et al., "Understanding the neurobiology of suicidal behavior", DEPRESS ANX, 14(3), 2001, pp. 164-176

Abstract

Our current knowledge about the neurobiology of suicide is still limited. Technical limitations and the complexity of the CNS are major obstacles. However, there is evidence for a hereditary disposition to suicide, which appears to be independent of diagnosis. Clinical, postmortem, genetic, and animal studies suggest that serotonin has a central role. The main regions of interest in the CNS have been the dorsal and median raphe nuclei in the midbrain that host the main serotonergic cell bodies and the prefrontal cortex, particularly the ventral PFC, innervated by the serotonergic system. In vivo and postmortem studies indicate serotonergic hypofunction in suicide and serious suicide attempts. This deficiency in turn can lead to a predisposition to impulsive and aggressive behavior, probably due to a breakdown in the inhibitory function of the ventral prefrontal cortex as a result of less serotonin input. In the context of this predisposition and the development of mental illness or other life stressors, the individual is at risk of acting on suicidal thoughts. Such deficient serotonin input into the PFC mayarise as a result of genetic, parenting, bead injury, and other effects. Identifying psychiatric, social, and environmental predictors of suicide arestudied to improve prediction and prevention of suicide. A better understanding of the neurobiology of suicide can help detect at risk populations and help develop better treatment interventions. (C) 2001 Wiley-Liss, Inc.

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Documento generato il 19/01/20 alle ore 06:15:39