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Titolo:
Risk and benefit of treatment of isolated systolic hypertension in the elderly: evidence from the Systolic Hypertension in Europe Trial
Autore:
Celis, H; Fagard, RH; Staessen, JA; Thijs, L;
Indirizzi:
Studiecoordinatiectr, Lab Hypertensie, B-3000 Louvain, Belgium Studiecoordinatiectr Louvain Belgium B-3000 sie, B-3000 Louvain, Belgium
Titolo Testata:
CURRENT OPINION IN CARDIOLOGY
fascicolo: 6, volume: 16, anno: 2001,
pagine: 342 - 348
SICI:
0268-4705(200111)16:6<342:RABOTO>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMBULATORY BLOOD-PRESSURE; WHITE-COAT HYPERTENSION; CORONARY HEART-DISEASE; CALCIUM-CHANNEL BLOCKADE; MYOCARDIAL-INFARCTION; PULSE PRESSURE; OLDER PATIENTS; ALZHEIMERS-DISEASE; CARDIOVASCULAR MORTALITY; ANTIHYPERTENSIVE THERAPY;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
72
Recensione:
Indirizzi per estratti:
Indirizzo: Celis, H Studiecoordinatiectr, Lab Hypertensie, Campus Gasthuisberg,Herestr 49, B-3000 Louvain, Belgium Studiecoordinatiectr Campus Gasthuisberg,Herestr 49 Louvain Belgium B-3000
Citazione:
H. Celis et al., "Risk and benefit of treatment of isolated systolic hypertension in the elderly: evidence from the Systolic Hypertension in Europe Trial", CURR OPIN C, 16(6), 2001, pp. 342-348

Abstract

The Syst-Eur trial investigated whether active treatment starting with thedihydropyridine calcium channel blocker (CCB) nitrendipine, could reduce the cardiovascular complications of isolated systolic hypertension (ISH) in the elderly. The intention-to-treat analysis showed that active treatment improved outcome. The per-protocol analysis largely confirmed these results. The effect of treatment on total and cardiovascular mortality might be attenuated in very old patients. Further analysis also suggested benefit in those patients who remained on nitrendipine monotherapy. Active treatment wasmore beneficial in patients with diabetes as compared with those without diabetes at entry and reduced the incidence of dementia by 50%. Analyses of data from the Ambulatory Blood Pressure Monitoring (ABPM) Side Project suggested that most of the benefit of treatment was seen in patients with a daytime systolic BP greater than or equal to 160 mm Hg. Finally, a meta-analysis partly based on Syst-Eur data showed that in older hypertensive patientspulse pressure and not mean pressure is the major determinant of cardiovascular risk. (C) 2001 Lippincott Williams & Wilkins, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 07:25:40