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Titolo:
Histamine and betahistine in the treatment of vertigo - Elucidation of mechanisms of action
Autore:
Lacour, M; Sterkers, O;
Indirizzi:
Univ Aix Marseille 1, Dept Integrat & Adaptat Neurobiol, CNRS, UMR 6562, F-13397 Marseille 20, France Univ Aix Marseille 1 Marseille France 20 2, F-13397 Marseille 20, France Univ Paris, Beaujon Hosp, Dept Otoneurol, Clichy, France Univ Paris Clichy France , Beaujon Hosp, Dept Otoneurol, Clichy, France Univ Paris, Fac Xavier Bichat, Clichy, France Univ Paris Clichy FranceUniv Paris, Fac Xavier Bichat, Clichy, France
Titolo Testata:
CNS DRUGS
fascicolo: 11, volume: 15, anno: 2001,
pagine: 853 - 870
SICI:
1172-7047(2001)15:11<853:HABITT>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
MEDIAL VESTIBULAR NUCLEUS; INNERVATING OTOLITH ORGANS; GUINEA-PIG; BLOOD-FLOW; SQUIRREL-MONKEY; FOS EXPRESSION; RAT-BRAIN; NEURONS; RECEPTORS; COMPENSATION;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
70
Recensione:
Indirizzi per estratti:
Indirizzo: Lacour, M Univ Aix Marseille 1, Dept Integrat & Adaptat Neurobiol, CNRS, UMR 6562, 52 Fac St Jerome,Case 361, F-13397 Marseille 20, France Univ Aix Marseille 1 52 Fac St Jerome,Case 361 Marseille France 20
Citazione:
M. Lacour e O. Sterkers, "Histamine and betahistine in the treatment of vertigo - Elucidation of mechanisms of action", CNS DRUGS, 15(11), 2001, pp. 853-870

Abstract

The aim of this review is to provide clinicians with a picture of the mechanisms by which: (i) histamine and histaminergic agonists act on the vestibular system both peripherally and centrally; and (ii) histaminergic agonists and antagonists interfere with the recovery process after peripheral vestibular lesion. We have focused on betahistine. a structural analogue of histamine with weak histamine H-1 receptor agonist and more potent H-3 receptor antagonist properties. to review the currently available data on the roleof the histaminergic system in the recovery process after peripheral vestibular deficits and the effects of histamine analogues in the clinical treatment of vertigo. This review provides new insights into the basic mechanisms by which betahistine improves vestibular compensation in animal models of unilateral vestibular dysfunction, and elucidates particularly the mechanisms of action ofthis at the level of the CNS. It is proposed that betahistine may reduce peripherally the asymmetric functioning of the sensory vestibular organs in addition to increasing vestibulocochlear blood flow by antagonising local H-3 heteroreceptors. Betahistine acts centrally by enhancing histamine synthesis within tuberomammillary nuclei of the posterior hypothalamus and histamine release within vestibularnuclei through antagonism of H-3 autoreceptors. This mechanism, together with less specific effects of betahistine on alertness regulation through cerebral H-1 receptors, should promote and facilitate central vestibular compensation. Elucidation of the mechanisms of action of betahistine is of particular interest for the treatment of vestibular and cochlear disorders and vertigo.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 08:40:56