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Titolo:
Autism and measles-mumps-rubella vaccination - Controversy laid to rest?
Autore:
DeStefano, F; Chen, RT;
Indirizzi:
Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30341 USA Natl Ctr BirthDefects & Dev Disabil Atlanta GA USA 30341 a, GA 30341 USA Ctr Dis Control & Prevent, Natl Immunizat Program, Atlanta, GA USA Ctr DisControl & Prevent Atlanta GA USA unizat Program, Atlanta, GA USA
Titolo Testata:
CNS DRUGS
fascicolo: 11, volume: 15, anno: 2001,
pagine: 831 - 837
SICI:
1172-7047(2001)15:11<831:AAMV-C>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
INFLAMMATORY-BOWEL-DISEASE; VIRUS; DISORDER; CHILDREN; ABSENCE; EVENTS; CAUSAL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: DeStefano, F Natl Ctr Birth Defects & Dev Disabil, 4770 Buford Highway NE,Mailstop F34,Atlanta, GA 30341 USA Natl Ctr Birth Defects & Dev Disabil 4770 Buford Highway NE,Mailstop F34 Atlanta GA USA 30341
Citazione:
F. DeStefano e R.T. Chen, "Autism and measles-mumps-rubella vaccination - Controversy laid to rest?", CNS DRUGS, 15(11), 2001, pp. 831-837

Abstract

It has been suggested that vaccination, particularly with measles-mumps-rubella (MMR) vaccine, may be related to the development of autism. The main evidence for a possible association is that the prevalence of autism has been increasing at the same time that infant vaccination coverage has increased, and that in some cases there is an apparent temporal association in which autistic characteristics are first noted shortly after vaccination. Although the prevalence of autism and similar disorders appears to have increased recently, it is not clear if this is an actual increase or the result ofincreased recognition and changes in diagnostic criteria. The apparent onset of autism in close proximity to vaccination may be a coincidental temporal association. The clinical evidence in support of an association derives from a series of 12 patients with inflammatory bowel conditions and regressive developmental disorders, mostly autism. The possibility that measles vaccine may cause autism through a persistent bowel infection has generated much interest, since it provides a possible biological mechanism. Epidemiological studies, however, have not found an association between MMR vaccination and autism. The epidemiological findings are consistent with current understanding of the pathogenesis of autism, which has a strong genetic component and in which the neurological defects probably occur early in embryonicdevelopment. It seems unlikely that a vaccination that is given after birth could cause autism. A minority of cases of autism may have onset after I year of age (regressive autism), but the single epidemiological study that included such cases did not find an association with MMR vaccination. Currently, the weight of the available epidemiological and related evidence doesnot support a causal association between MMR vaccine, or any other vaccineor vaccine constituent, and autism.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/04/20 alle ore 02:39:39