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Titolo:
Immunohistochemical localization of phosphoinositide 3-kinase in brains with multiple system atrophy
Autore:
Nakamura, S; Kawamoto, Y; Kitajima, K; Honjo, Y; Matsuo, A; Nakano, S; Akiguchi, I;
Indirizzi:
Osaka City Juso Hosp, Dept Neurol, Osaka 5320023, Japan Osaka City Juso Hosp Osaka Japan 5320023 pt Neurol, Osaka 5320023, Japan Kyoto Univ, Fac Med, Dept Neurol, Kyoto 606, Japan Kyoto Univ Kyoto Japan 606 Univ, Fac Med, Dept Neurol, Kyoto 606, Japan
Titolo Testata:
CLINICAL NEUROPATHOLOGY
fascicolo: 6, volume: 20, anno: 2001,
pagine: 243 - 247
SICI:
0722-5091(200111/12)20:6<243:ILOP3I>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
PHOSPHATIDYLINOSITOL 3-KINASE; PROTEIN-KINASE; CYTOPLASMIC INCLUSIONS; GROWTH-FACTOR; AKT; ACTIVATION; PI(3)K; PHOSPHORYLATION; APOPTOSIS; SURVIVAL;
Keywords:
phosphoinositide 3-kinase; P13K; multiple system atrophy; MSA; oligodendrocyte; Purkinje cell; apoptosis; PKB/Akt; BAD;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Nakamura, S Osaka City Juso Hosp, Dept Neurol, Osaka 5320023, Japan Osaka City Juso Hosp Osaka Japan 5320023 saka 5320023, Japan
Citazione:
S. Nakamura et al., "Immunohistochemical localization of phosphoinositide 3-kinase in brains with multiple system atrophy", CLIN NEUR, 20(6), 2001, pp. 243-247

Abstract

Oligodendrocytes have been shown to display some morphological characteristics of apoptosis in MSA. The accumulated evidence shows that phosphoinositide 3-kinase (P13K) is closely associated with the regulation of apoptosis. Thus, we examined immunohistochemically P13K in the cerebellum and pons from autopsy samples with MSA. In control tissues, P13K was immunostained in some neurons and a few oligodendrocytes. In MSA samples, the larger number of oligodendrocytes was observed in the pons and cerebellum. Furthermore, some neurons were strongly immunolabeled in MSA samples. The recent study has shown that P13K phosphorylates PKB/Akt which phosphorylates BAD resultingin the cessation of apoptotic process. The present results suggest that P13K is upregulated in oligodendrocytes and some neurons in MSA, possibly in response to the apoptotic signals to these cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 13:16:52