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Titolo:
Carvedilol in the failing heart
Autore:
Lombardi, WL; Gilbert, EM;
Indirizzi:
Univ Utah, Sch Med, Div Cardiol, Salt Lake City, UT USA Univ Utah Salt Lake City UT USA Med, Div Cardiol, Salt Lake City, UT USA
Titolo Testata:
CLINICAL CARDIOLOGY
fascicolo: 12, volume: 24, anno: 2001,
pagine: 757 - 766
SICI:
0160-9289(200112)24:12<757:CITFH>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
IDIOPATHIC DILATED CARDIOMYOPATHY; HUMAN VENTRICULAR MYOCARDIUM; BETA-ADRENERGIC-BLOCKADE; RECEPTOR DOWN-REGULATION; DOUBLE-BLIND; FAILURE; TERM; METOPROLOL; SURVIVAL; SYMPTOMS;
Keywords:
heart failure; beta-adrenergic antagonist; carvedilol; cardiomyopathy;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
72
Recensione:
Indirizzi per estratti:
Indirizzo: Gilbert, EM 4A-100 UUHSC,50 N Med Dr, Salt Lake City, UT 84132 USA 4A-100UUHSC,50 N Med Dr Salt Lake City UT USA 84132 4132 USA
Citazione:
W.L. Lombardi e E.M. Gilbert, "Carvedilol in the failing heart", CLIN CARD, 24(12), 2001, pp. 757-766

Abstract

Patients with chronic heart failure due to left ventricular systolic dysfunction of ischemic or nonischemic etiology have shown improvement in morbidity and mortality with carvedilol therapy. In patients with symptomatic (New York Heart Association class II-IV) heart failure, carvedilol improves left ventricular ejection fraction and clinical status, and slows disease progression, reducing the combined risk of mortality and hospitalization. Despite the overwhelming evidence for their benefit, there continues to be a large treatment gap between those who would derive benefit and those who actually receive the drug. In this article, the pharmacology, clinical trial evidence, and the potential differences between carvedilol and other beta blockers are discussed. Carvedilol provides powerful therapy in the treatment of chronic heart failure caused by a variety of etiologies and in a wide array of clinical settings.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 12:20:51