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Titolo:
Association of plasma antibodies against the inducible Hsp70 with hypertension and harsh working conditions
Autore:
Wu, TC; Ma, JX; Chen, S; Sun, YH; Xiao, CF; Gao, YJ; Wang, RB; Poudrier, J; Dargis, M; Currie, RW; Tanguay, RM;
Indirizzi:
Huazhong Univ Sci & Technol, Tongji Med Coll, Inst Occupat Med, Wuhan 430030, Peoples R China Huazhong Univ Sci & Technol Wuhan Peoples R China 430030 Peoples R China Anhui Med Univ, Dept Epidemiol, Hefei 230032, Peoples R China Anhui Med Univ Hefei Peoples R China 230032 efei 230032, Peoples R China Dalhousie Univ, Dept Anat & Neurobiol, Halifax, NS B3H 4H7, Canada Dalhousie Univ Halifax NS Canada B3H 4H7 iol, Halifax, NS B3H 4H7, Canada Univ Laval, Fac Med, Dept Med, Lab Cell & Dev Genet, St Foy, PQ G1K 7P4, Canada Univ Laval St Foy PQ Canada G1K 7P4 Dev Genet, St Foy, PQ G1K 7P4, Canada
Titolo Testata:
CELL STRESS & CHAPERONES
fascicolo: 4, volume: 6, anno: 2001,
pagine: 394 - 401
SICI:
1355-8145(200110)6:4<394:AOPAAT>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEAT-SHOCK PROTEINS; STRESS PROTEINS; SERUM ANTIBODIES; CAROTID ATHEROSCLEROSIS; BLOOD-PRESSURE; GENE; HEAT-SHOCK-PROTEIN-60; EXPRESSION; MICE; AUTOANTIBODIES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Wu, TC Huazhong Univ Sci & Technol, Tongji Med Coll, Inst Occupat Med, Wuhan 430030, Peoples R China Huazhong Univ Sci & Technol Wuhan Peoples R China 430030 R China
Citazione:
T.C. Wu et al., "Association of plasma antibodies against the inducible Hsp70 with hypertension and harsh working conditions", CELL STR CH, 6(4), 2001, pp. 394-401

Abstract

Autoantibodies against certain stress or heat shock proteins (Hsps) may play a role in the pathogenesis and/ or prognosis of some diseases. Using immunoblotting with human recombinant Hsps and univariate and multivariate logistic regression models, we have investigated the presence of antibodies against Hsp70, the inducible member of the 70-kDa family of heat shock proteins, and analyzed its possible association with hypertension and working conditions. Plasma and serum were collected from 764 steel mill workers from 6work sites exposed to (1) severe noise; (2) severe noise and dust; (3) noise, dust, and heat; (4) noise and heat; (5) severe noise and heat; and (6) office conditions (control). Workers with prolonged exposure to stresses such as noise, dust, and high temperature and a combination of these in the workplace had a high incidence (26.6% to 40.2%) of antibodies to Hsp70 compared to the lowest incidence (18.6%) of antibodies to Hsp70 in the control group of office workers. Moreover, there was a statistical association of antibodies against Hsp70 with hypertension. The statistical correlation between the presence of antibodies to Hsp70 and hypertension is higher in the group of workers with blood pressure of 160/95 mmHg than in the 140/90-mmHg group after excluding possible effects of the workplace stresses. These results suggest that harsh workplace conditions can increase the production of antibodies against Hsp70 and that the presence of antibodies to this stressprotein may be associated with hypertension. The precise mechanism for theelevation of antibodies against Hsps by environmental and workplace stresses and their relation to hypertension remains to be established.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 23:42:39