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Titolo:
The nuclear orphan receptor TR4 promotes proliferation of myeloid progenitor cells
Autore:
Koritschoner, NP; Madruga, J; Knespel, S; Blendinger, G; Anzinger, B; Otto, A; Zenke, M; Bartunek, P;
Indirizzi:
Max Delbruck Ctr Mol Med, D-13122 Berlin, Germany Max Delbruck Ctr Mol Med Berlin Germany D-13122 D-13122 Berlin, Germany Inst Mol Genet, Prague 16637 6, Czech Republic Inst Mol Genet Prague Czech Republic 16637 6 gue 16637 6, Czech Republic
Titolo Testata:
CELL GROWTH & DIFFERENTIATION
fascicolo: 11, volume: 12, anno: 2001,
pagine: 563 - 572
SICI:
1044-9523(200111)12:11<563:TNORTP>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
RETINOIC ACID RECEPTOR; MULTIPOTENT HEMATOPOIETIC PROGENITORS; STEROID-HORMONE RECEPTORS; ERYTHROID PROGENITORS; GLUCOCORTICOID RECEPTOR; MONOCLONAL-ANTIBODIES; DNA-BINDING; IN-VITRO; V-MYB; TRANSCRIPTION FACTORS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
61
Recensione:
Indirizzi per estratti:
Indirizzo: Zenke, M Max Delbruck Ctr Mol Med, Robert Rossle Str 10, D-13122 Berlin, Germany Max Delbruck Ctr Mol Med Robert Rossle Str 10 Berlin Germany D-13122
Citazione:
N.P. Koritschoner et al., "The nuclear orphan receptor TR4 promotes proliferation of myeloid progenitor cells", CELL GROWTH, 12(11), 2001, pp. 563-572

Abstract

Nuclear receptors represent key regulators in cell proliferation, differentiation, and development. Here we demonstrate that the nuclear orphan receptor TR4 is highly expressed in hematopoietic cells and tissues and have analyzed the impact of TR4 in this cell compartment. We show that TR4, when ectopically expressed in bone marrow cells via retrovirus vector, promotes proliferation of myeloid progenitor cells. Cells represent promyelocytes as judged by morphological features, expression of cell surface molecules, and specific markers like Mim-1 and CAAT/enhancer binding protein beta. We alsodemonstrate that the growth promoting activity of TR4 is not exclusively dependent on its association with DNA, because expression of a mutated TR4 version devoid of, its DNA binding domain exhibits a similar proliferative potential as wild-type TR4. In conclusion, these data position the orphan receptor TR4 as an important regulator of myeloid progenitor cell proliferation and development.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 20:40:59