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Titolo:
Regulation of p53 target gene expression by cisplatin-induced extracellular signal-regulated kinase
Autore:
DeHaan, RD; Yazlovitskaya, EM; Persons, DL;
Indirizzi:
Univ Kansas, Med Ctr, Dept Pathol & Lab Med, Clin Lab 1213, Kansas City, KS 66160 USA Univ Kansas Kansas City KS USA 66160 Lab 1213, Kansas City, KS 66160 USA
Titolo Testata:
CANCER CHEMOTHERAPY AND PHARMACOLOGY
fascicolo: 5, volume: 48, anno: 2001,
pagine: 383 - 388
SICI:
0344-5704(200111)48:5<383:ROPTGE>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
P53-REGULATED PROTEIN GADD45; CELL-CYCLE CHECKPOINT; P53-DEPENDENT APOPTOSIS; GROWTH ARREST; DNA DAMAGE; ACTIVATION; INHIBITION; G(2)/M; CANCER; BCL-2;
Keywords:
ERK; cisplatin; p53; apoptosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Persons, DL Univ Kansas, Med Ctr, Dept Pathol & Lab Med, Clin Lab 1213, 3901 Rainbow Blvd, Kansas City, KS 66160 USA Univ Kansas 3901 Rainbow Blvd Kansas City KS USA 66160 160 USA
Citazione:
R.D. DeHaan et al., "Regulation of p53 target gene expression by cisplatin-induced extracellular signal-regulated kinase", CANC CHEMOT, 48(5), 2001, pp. 383-388

Abstract

The extracellular signal-regulated kinase (ERK) pathway is among several signal transduction pathways that are activated in response to exposure to the DNA damage-inducing chemotherapeutic agent cisplatin. We have previouslyreported that inhibition of cisplatin-induced ERK activity enhances sensitivity to cisplatin. Furthermore, we have demonstrated that cisplatin-induced ERK activation is required for optimal p53 protein accumulation followingcisplatin-induced DNA damage. In the present study, we expanded our investigations to examine the effect of cisplatin-induced ERK activation on the expression of p53-targeted genes that have been shown to be important in thecellular response to DNA damage including Bax, Bcl-2, Bcl-(xl), Cyclin G, Gadd45, p21(WAF1), and Mdm.2. In the ovarian carcinoma cell line A2780, cisplatin was shown to induce expression of p21(WAF1), Gadd45 and Mdm2, but cisplatin had no effect on expression of Bax, Bcl-2, Bcl-(xl), or Cyclin G. Inhibition of cisplatin-induced ERK activity by PD98059 resulted in decreased levels of p21(WAF1), Gadd45 and Mdm2. These results provide evidence thatERK activity during the cisplatin DNA damage response, regulates in part, these cell cycle control (p21(WAF1), Gadd45), DNA repair (Gadd45) and p53-regulatory (Mdm2) proteins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 01:35:08