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Titolo:
Past exposure to vaccines and subsequent risk of Alzheimer's disease
Autore:
Verreault, R; Laurin, D; Lindsay, J; De Serres, G;
Indirizzi:
Univ Laval, CHU Quebec, Geriatr Res Unit, Ctr Hebergement St Augustin, Beauport, PQ G1C 1Z2, Canada Univ Laval Beauport PQ Canada G1C 1Z2 ustin, Beauport, PQ G1C 1Z2, Canada Univ Laval, Dept Social & Prevent Med, St Foy, PQ G1K 7P4, Canada Univ Laval St Foy PQ Canada G1K 7P4 event Med, St Foy, PQ G1K 7P4, Canada Univ Ottawa, Dept Epidemiol & Community Hlth, Ottawa, ON K1Y 4E9, Canada Univ Ottawa Ottawa ON Canada K1Y 4E9 ity Hlth, Ottawa, ON K1Y 4E9, Canada Hlth Canada, Ctr Chron Dis Prevent & Control, Surveillance & Risk Assessment Div, Ottawa, ON, Canada Hlth Canada Ottawa ON Canada e & Risk Assessment Div, Ottawa, ON, Canada Ctr Sante Publ Quebec, Quebec City, PQ, Canada Ctr Sante Publ Quebec Quebec City PQ Canada bec, Quebec City, PQ, Canada
Titolo Testata:
CANADIAN MEDICAL ASSOCIATION JOURNAL
fascicolo: 11, volume: 165, anno: 2001,
pagine: 1495 - 1498
SICI:
0820-3946(20011127)165:11<1495:PETVAS>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
14
Recensione:
Indirizzi per estratti:
Indirizzo: Verreault, R Univ Laval, CHU Quebec, Geriatr Res Unit, Ctr Hebergement St Augustin, 2135 Terrasse Cadieux, Beauport, PQ G1C 1Z2, Canada Univ Laval 2135 Terrasse Cadieux Beauport PQ Canada G1C 1Z2 a
Citazione:
R. Verreault et al., "Past exposure to vaccines and subsequent risk of Alzheimer's disease", CAN MED A J, 165(11), 2001, pp. 1495-1498

Abstract

Background: It has been suggested that changes to the immune system could be a factor in age-related conditions such as Alzheimer's disease. Our objective was to examine the association between past exposure to conventional vaccines and risk of Alzheimer's disease. Methods: We analyzed data from a representative community sample of subjects 65 years of age or older participating in the Canadian Study of Health and Aging, a prospective cohort study of dementia. Screening and clinical evaluations were done at both baseline and follow-up. Past exposure to vaccines, was assessed at baseline by means of a self-administered questionnaire. Results: Of the 4392 eligible subjects who were cognitively unimpaired andfor whom vaccine information was available at baseline (in 1991-1992) and who completed follow-up 5 years later (in 1996-1997), 527 were diagnosed ashaving cognitive impairment or dementia other than Alzheimer's disease andwere excluded from these analyses. Of the remaining subjects, 3682 were cognitively unimpaired at follow-up and 183 were newly diagnosed as having Alzheimer's disease. After adjustment for age, sex and education, past exposure to vaccines against diphtheria or tetanus, poliomyelitis and influenza was associated with lower risk for Alzheimer's disease (odds ratio [OR] 0.41, 95% confidence interval [CI] 0.27-0.62; OR 0.60, 95% CI 0.37-0.99; and OR0.75, 95% Cl 0.54-1.04 respectively) than no exposure to these vaccines. Interpretation: Past exposure to vaccines against diphtheria or tetanus, poliomyelitis and influenza may protect against subsequent development of Alzheimer's disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/08/20 alle ore 23:31:07