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Titolo:
Changes in cerebral blood flow velocity elicited by surgical stimulation are dependent on the PaCO2 level
Autore:
Kawata, R; Matsumoto, M; Haranishi, Y; Ishida, K; Nakakimura, K; Sakabe, T;
Indirizzi:
Yamaguchi Univ, Sch Med, Dept Anesthesiol Resuscitol, Yamaguchi 7558505, Japan Yamaguchi Univ Yamaguchi Japan 7558505 uscitol, Yamaguchi 7558505, Japan
Titolo Testata:
CANADIAN JOURNAL OF ANAESTHESIA-JOURNAL CANADIEN D ANESTHESIE
fascicolo: 10, volume: 48, anno: 2001,
pagine: 1029 - 1033
SICI:
0832-610X(200111)48:10<1029:CICBFV>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
ISOFLURANE ANESTHESIA; NERVE STIMULATION; NEURAL ACTIVITY; CONSUMPTION; METABOLISM; RESPONSES; INCISION; STRESS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Kawata, R Yamaguchi Univ, Sch Med, Dept Anesthesiol Resuscitol, 1-1-1 Minami Kogushi, Yamaguchi 7558505, Japan Yamaguchi Univ 1-1-1 Minami Kogushi Yamaguchi Japan 7558505 pan
Citazione:
R. Kawata et al., "Changes in cerebral blood flow velocity elicited by surgical stimulation are dependent on the PaCO2 level", CAN J ANAES, 48(10), 2001, pp. 1029-1033

Abstract

Purpose: To investigate the influence of PaCO2 manipulation on the cerebral hemodynamic response to surgical stimulation. Methods: Twenty-one female patients undergoing elective gynecological surgery performed through a lower median abdominal incision were enrolled. After obtaining steady general anesthesia with 1.7% sevoflurane and 60% nitrousoxide, the patients were randomly assigned to three groups, hypocapnia (PaCO2 = 30 mmHg), normocapnia (PaCO2 = 38 mmHg), and hypercapnia (PaCO2 = 44 mmHg) groups. The changes in mean blood flow velocity in the middle cerebral artery (Vmca) were evaluated using transcranial Doppler ultrasonography during nine minutes after surgical incision. Results: The change in Vmca (Delta Vmca) with surgical incision during hypercapnia (30-36 cm(.)sec(-1)) was significantly greater than during normocapnia (20-22 cm(.)sec(-1)) and hypocapnia (13-15 cm(.)sec(-1)). The Delta Vmca in the hypocapnia group was significantly smaller than in the normocapnia group. Arterial blood pressure increased with incision but there was no significant difference among the three groups. Conclusion: Cerebral hemodynamic changes evoked by surgical stimulation are attenuated by hypocapnia and are augmented by hypercapnia, even within a clinically relevant range of PaCO2.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 09:51:25