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Titolo:
Flumazenil improves cognitive and neuromotor emergence and attenuates shivering after halothane-, enflurane- and isoflurane-based anesthesia
Autore:
Weinbroum, AA; Geller, E;
Indirizzi:
Tel Aviv Sourasky Med Ctr, PostAnesthesia Care Unit, IL-64239 Tel Aviv, Israel Tel Aviv Sourasky Med Ctr Tel Aviv Israel IL-64239 4239 Tel Aviv, Israel Tel Aviv Sourasky Med Ctr, Dept Anesthesiol & Crit Care, Tel Aviv, Israel Tel Aviv Sourasky Med Ctr Tel Aviv Israel & Crit Care, Tel Aviv, Israel Tel Aviv Univ, Sackler Fac Med, IL-69978 Tel Aviv, Israel Tel Aviv Univ Tel Aviv Israel IL-69978 ac Med, IL-69978 Tel Aviv, Israel
Titolo Testata:
CANADIAN JOURNAL OF ANAESTHESIA-JOURNAL CANADIEN D ANESTHESIE
fascicolo: 10, volume: 48, anno: 2001,
pagine: 963 - 972
SICI:
0832-610X(200111)48:10<963:FICANE>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
BENZODIAZEPINE INVERSE AGONISTS; CHLORIDE CHANNEL COMPLEX; NITROUS-OXIDE; RAT; HUMANS; MICE; DOGS; ANTAGONISM; PROPOFOL; CURRENTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Weinbroum, AA Tel Aviv Sourasky Med Ctr, PostAnesthesia Care Unit, 6 Weizman St, IL-64239 Tel Aviv, Israel Tel Aviv Sourasky Med Ctr 6 Weizman St TelAviv Israel IL-64239
Citazione:
A.A. Weinbroum e E. Geller, "Flumazenil improves cognitive and neuromotor emergence and attenuates shivering after halothane-, enflurane- and isoflurane-based anesthesia", CAN J ANAES, 48(10), 2001, pp. 963-972

Abstract

Purpose: To conduct a randomized, placebo-controlled, double-blinded, clinical experiment testing the hypothesis that flumazenil, a benzodiazepine antagonist, may affect recovery from halothane-, enflurane- and isoflurane-based anesthesia. Method: Patients who underwent surgery under N2O/O-2 plus halothane (n = 100), enflurane (n = 100) or isoflurane (n = 70) anesthesia were administered flumazenil I mg or placebo upon emergence from anesthesia, and their postanesthesia vital signs, vigilance, neurological recovery, shivering, amnesia reversal, and general subjective feeling were assessed. Results: A ten-point vigilance score showed better recovery of flumazenil-treated patients compared to those who received placebo (60-min after halothane anesthesia: 9.9 +/- 0.1 vs 9.5 +/- 0.2, P < 0.01; after enflurane: 10 /- 0 vs 9.4 +/- 0.2, P < 0.01; after isoflurane: 10.0 +/- 0 vs 9.3 +/- 0.1, P < 0.01 Halothane- and enflurane- flumazenil-treated patients (but not isoflurane) reached a better neurological score (2.97 +/- 0.05 or 3 +/- 0) compared to placebo (2.8 +/- 0.4 or 2.6 +/- 0.4, P < 0.01), respectively. Reversal of amnesia was superior in the flumazenil group at 60 min and at 24 hr postsurgery, and more flumazenil patients rated recovery as "pleasant". Flumazenil patients shivered less than placebo patients despite their lowercore temperature (at 30 min: halothane: 11% vs 28%, P < 0.05; enflurane: 11% vs 30%, P < 0.05; isoflurane: 17% for both groups). Conclusion: Flumazenil improves recovery of high cortical and neuromotor functions following halothane, enflurane and isoflurane anesthesia, reduces shivering and improves the overall quality of emergence, including patients' subjective feeling.

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Documento generato il 14/07/20 alle ore 05:34:21