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Titolo:
Birth weight and the risk of depressive disorder in late life
Autore:
Thompson, C; Syddall, H; Rodin, I; Osmond, C; Barker, DJP;
Indirizzi:
Univ Southampton, Environm Epidemiol Unit, Southampton, Hants, England Univ Southampton Southampton Hants England , Southampton, Hants, England Univ Southampton, Community Clin Sci Res Div, Southampton, Hants, England Univ Southampton Southampton Hants England , Southampton, Hants, England
Titolo Testata:
BRITISH JOURNAL OF PSYCHIATRY
, volume: 179, anno: 2001,
pagine: 450 - 455
SICI:
0007-1250(200111)179:<450:BWATRO>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
ISCHEMIC-HEART-DISEASE; GROWTH-HORMONE SECRETION; BIPOLAR DISORDER; MAJOR DEPRESSION; THYROID-FUNCTION; PRENATAL FAMINE; FOLLOW-UP; SCHIZOPHRENIA; COHORT; MEN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Thompson, C Royal S Hants Hosp, Dept Psychiat, Brintons Terrace, Southampton SO14 0YG,Hants, England Royal S Hants Hosp Brintons Terrace Southampton Hants England SO14 0YG
Citazione:
C. Thompson et al., "Birth weight and the risk of depressive disorder in late life", BR J PSYCHI, 179, 2001, pp. 450-455

Abstract

Background Low birth weight is a risk factor for coronary heart disease, diabetes, stroke and hypertension, Depression is highly associated with these conditions. Aims To examine the association between birth weight and depression in late life. Method A total of 882 singleton term births in the 1920s had contemporary records of birth weight and weight at I year. At 68 years all completed theGeriatric Depression Scale and 867 completed the Geriatric Mental State Examination. A logistic regression was used to analyse the associations between depression, birth weight and weight at I year while adjusting for known risk factors. Results Current social class, social class at birth, recent bereavement, social isolation and physical illness increased the risk of depression. After adjusting for these and weight at I year, the odds ratios for depression among men, but not women, rose incrementally with decreasing birth weight (1.0, 12.8; for continuous variable, P < 0.007). Conclusions Foetal undernutrition predisposes men to depression in late adult life. If replicated, these results would suggest a neurodevelopmental aetiology of depression, possibly mediated by programming of the hypothalamic-pituitary-adrenal axis. Declaration of interest None.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 09:13:59