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Titolo:
In vitro neuronal and vascular responses to 5-HT in rats chronically exposed to MDMA
Autore:
Cannon, DM; Keenan, AK; Guiry, PJ; Buon, C; Baird, AW; McBean, GJ;
Indirizzi:
Univ Coll Dublin, Conway Inst Biomol & Biomed Res, Dept Biochem, Dublin 4,Ireland Univ Coll Dublin Dublin Ireland 4 ed Res, Dept Biochem, Dublin 4,Ireland Univ Coll Dublin, Conway Inst Biomol & Biomed Res, Dept Pharmacol, Dublin 4, Ireland Univ Coll Dublin Dublin Ireland 4 Res, Dept Pharmacol, Dublin 4, Ireland Univ Coll Dublin, Conway Inst Biomol & Biomed Res, Dept Chem, Dublin 4, Ireland Univ Coll Dublin Dublin Ireland 4 omed Res, Dept Chem, Dublin 4, Ireland
Titolo Testata:
BRITISH JOURNAL OF PHARMACOLOGY
fascicolo: 7, volume: 134, anno: 2001,
pagine: 1455 - 1460
SICI:
0007-1188(200112)134:7<1455:IVNAVR>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
ECSTASY; 3,4-METHYLENEDIOXYMETHAMPHETAMINE; METHYLENEDIOXYMETHAMPHETAMINE; SEROTONIN; BRAIN; ANALOGS; RELEASE; 3,4-METHYLENEDIOXYAMPHETAMINE; 5-HYDROXYTRYPTAMINE; SYNAPTOSOMES;
Keywords:
MDMA; 5-HT; synaptosomal re-uptake; 5-HT-induced aortic contraction; aortic [H-3]5-HT re-uptake;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: McBean, GJ Univ Coll Dublin, Conway Inst Biomol & Biomed Res, Dept Biochem, Dublin 4,Ireland Univ Coll Dublin Dublin Ireland 4 t Biochem, Dublin 4,Ireland
Citazione:
D.M. Cannon et al., "In vitro neuronal and vascular responses to 5-HT in rats chronically exposed to MDMA", BR J PHARM, 134(7), 2001, pp. 1455-1460

Abstract

1 This study examined the effects of chronic exposure of rats to 3,4-methylenedioxymethamphetamine (MDMA) on [H-3]5-hydroxytryptamine ([H-3]5-HT) re-uptake into purified rat brain synaptosomes, 5-HT-induced isometric contraction of aortic rings and [H-3]5-HT re-uptake into rat aorta.2 Rats were administered MDMA (20 mg kg(-1) i.p.) twice daily over 4 days. One, 7, 14 or 21 days post treatment, whole brain synaptosomes and descending thoracic aortic rings were prepared for investigation.3 Chronic MDMA treatment significantly reduced the maximum rate (V-max) ofspecific high-affinity [H-3]5-HT re-uptake 1 day after treatment and for up to 21 days post-final administration of MDMA. Direct application of MDMA (100 muM) abolished synaptosomal re-uptake of [H-3]5-HT in vitro.4 Chronic MDMA administration significantly reduced the maximum contraction (E-max) to 5-HT at 1 and 7 days after treatment, but not at 14 or 21 days.5 Chronic MDMA administration had no effect on sodium-dependent [H-3]5-HT re-uptake into aorta 1 day after treatment, nor did 100 muM MDMA have any direct effect on [H-3]5-HT uptake into aortic rings in vitro.6 These results show, for the first time, an altered responsiveness of vascular tissue to MDMA after chronic administration. In addition, they demonstrate a difference in the sensitivity of central and peripheral 5-HT uptakesystems to chronic MDMA exposure, and suggest that the action of MDMA in the cardiovascular system does not arise from a direct effect of MDMA on peripheral 5-HT transport.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 15:50:18