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Titolo:
The effects of dentate granule cell destruction on behavioural activity and Fos protein expression induced by systemic methamphetamine in rats
Autore:
Tani, K; Iyo, M; Matsumoto, H; Kawai, M; Suzuki, K; Iwata, Y; Won, T; Tsukamoto, T; Sekine, Y; Sakanoue, M; Hashimoto, K; Ohashi, Y; Takei, N; Mori, N;
Indirizzi:
Hamamatsu Univ, Sch Med, Dept Psychiat & Neurol, Hamamatsu, Shizuoka 4313192, Japan Hamamatsu Univ Hamamatsu Shizuoka Japan 4313192 , Shizuoka 4313192, Japan Welfide Co, Div Pharmaceut Res, Tokyo Labs, Iruma 3580026, Japan Welfide Co Iruma Japan 3580026 eut Res, Tokyo Labs, Iruma 3580026, Japan
Titolo Testata:
BRITISH JOURNAL OF PHARMACOLOGY
fascicolo: 7, volume: 134, anno: 2001,
pagine: 1411 - 1418
SICI:
0007-1188(200112)134:7<1411:TEODGC>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUCLEUS ACCUMBENS SEPTI; FREELY-MOVING RATS; PREFRONTAL CORTEX; VENTRAL STRIATUM; DOPAMINE RELEASE; FRONTAL-CORTEX; HIPPOCAMPAL MODULATION; ANTEROGRADE TRANSPORT; LOCOMOTOR-ACTIVITY; INDUCED ROTATION;
Keywords:
dentate granule cell; nucleus accumbens; colchicine; methamphetamine; locomotor activity; rotation; Fos protein;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Suzuki, K Hamamatsu Univ, Sch Med, Dept Psychiat & Neurol, 1-20-1 Handayama, Hamamatsu, Shizuoka 4313192, Japan Hamamatsu Univ 1-20-1 Handayama Hamamatsu Shizuoka Japan 4313192
Citazione:
K. Tani et al., "The effects of dentate granule cell destruction on behavioural activity and Fos protein expression induced by systemic methamphetamine in rats", BR J PHARM, 134(7), 2001, pp. 1411-1418

Abstract

1 We destroyed dentate granule cells unilaterally or bilaterally by means of intrahippocampal injection of colchicine in rats. Subsequently, we observed behavioural changes following the intraperitoneal injection of 2 mg kg(-1) methamphetamine or saline, in addition to quantitatively assessing Fos protein expression in several brain regions, including the medial prefrontal cortex, cingulate cortex, piriform cortex, dorsal striatum, and nucleus accumbens.2 Bilaterally lesioned animals, when administered saline, showed a marked increase in locomotor activity compared with those of non-lesioned animals. With respect to the methamphetamine response, bilateral destruction resulted in a marked enhancement of locomotor activity, while the unilateral destruction led to a marked increase in rotation predominantly contralateral tothe lesioned side, with no identifiable change in locomotor activity.3 Bilaterally lesioned animals, when administered saline and having undergone an immunohistological examination, showed a marked increase in Fos expression in both sides of the nucleus accumbens. Bilaterally lesioned animalsadministered methamphetamine showed a marked increase in Fos expression inthe right and left sides of all regions tested. Unilaterally lesioned animals administered methamphetamine showed a significant and bilateral enhancement in Fos expression in the medial prefrontal and cingulate cortices, anda marked and unilateral (ipsilateral to the lesioned side) enhancement of Fos protein in the piriform cortex, dorsal striatum, and nucleus accumbens.4 The present findings suggest that dentate granule cells regulate methamphetamine-associated behavioural changes through the function of widespread areas of the brain, mostly the nucleus accumbens.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 11:10:53