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Titolo:
Venous thromboembolism during pregnancy: a retrospective study of enoxaparin safety in 624 pregnancies
Autore:
Lepercq, J; Conard, J; Borel-Derlon, A; Darmon, JY; Boudignat, O; Francoual, C; Priollet, P; Cohen, C; Yvelin, N; Schved, JF; Tournaire, M; Borg, JY;
Indirizzi:
Hop St Vincent de Paul, Serv Gynecol Obstet, F-75674 Paris 14, France Hop St Vincent de Paul Paris France 14 Obstet, F-75674 Paris 14, France Hop Hotel Dieu, Serv Hematol Biol, Paris, France Hop Hotel Dieu Paris France otel Dieu, Serv Hematol Biol, Paris, France CHRU, Lab Hematol Hemostase, Caen, France CHRU Caen FranceCHRU, Lab Hematol Hemostase, Caen, France Aventis SA, Dept Cardiovasc Labs Rhone Poulenc Rorer, Montrouge, France Aventis SA Montrouge France Labs Rhone Poulenc Rorer, Montrouge, France Aventis SA, Dept Pharmacovigilance Labs Rhone Poulenc Rorer, Montrouge, France Aventis SA Montrouge France Labs Rhone Poulenc Rorer, Montrouge, France Hop St Joseph, Serv Med Vasc, F-75674 Paris, France Hop St Joseph Paris France F-75674 Serv Med Vasc, F-75674 Paris, France CHU Montpellier, Hop St Eloi, Hematol Lab, Montpellier, France CHU Montpellier Montpellier France oi, Hematol Lab, Montpellier, France Hop Charles Nicolle, Hematol Lab, Rouen, France Hop Charles Nicolle Rouen France es Nicolle, Hematol Lab, Rouen, France
Titolo Testata:
BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY
fascicolo: 11, volume: 108, anno: 2001,
pagine: 1134 - 1140
SICI:
1470-0328(200111)108:11<1134:VTDPAR>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
MOLECULAR-WEIGHT HEPARIN; UNFRACTIONATED HEPARIN; 2ND TRIMESTER; THROMBOPROPHYLAXIS; WOMEN; THERAPY; THROMBOPHILIA; EXPERIENCE; PLACENTA; CROSS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Lepercq, J Hop St Vincent de Paul, Serv Gynecol Obstet, 82 Ave Denfert Rochereau, F-75674 Paris 14, France Hop St Vincent de Paul 82 Ave Denfert Rochereau Paris France 14
Citazione:
J. Lepercq et al., "Venous thromboembolism during pregnancy: a retrospective study of enoxaparin safety in 624 pregnancies", BR J OBST G, 108(11), 2001, pp. 1134-1140

Abstract

Objective To assess the maternal, fetal and neonatal safety of enoxaparin in pregnant women Alto require antithrombotic therapy. Design Retrospective analysis of case note,,, of women who received enoxaparin during pregnancy, Irrespective of close, duration and reason for treatment. Setting Fifty-five French perinatal centres. Sample Data from 624 pregnancies in 604 women between 1988 and 1997. The incidence of previous thromboembolism was 29.8%, known thrombophilia 15.2%. Methods Indication. regimen of enoxaparin and outcome measures were reported for each pregnancy. Information was obtained from case records. validated by research staff and analysed hv an independent scientific committee,Main outcome measures Incidence. seriousness and causality of maternal, fetal and neonatal adverse events, pregnancy outcome. and incidence of venousthromboembolism. Results Enoxaparin was administered for treatment of an acute episode in 49 cases and for thromboprophylaxis in 574 cases. Serious maternal haemorrhage Occurred in 11 cases during pregnancy (1.8%), one being reasonably related to enoxaparin. and in nine cases at delivers (1.4%) all unrelated to enoxaparin. Maternal thrombocytopenia was reported in 10 cases (1.6%) mo beingserious but unrelated to enoxaparin. Eight pregnancies ended in stillbirth(1.1%). Among the 693 lice birth,,. 17 major congenital abnormalities (2.5%) and 10 serious neonatal haemorrhages ( 1.4%) were reported. None of the fetal Or neonatal adverse events was related to enoxaparin. Eight venous thromboembolic events (1.3%) were reported. Conclusions The incidence of adverse events reported could he explained bythe high risk profile of the study population. Overall, this retrospectivestudy suggests enoxaparin is well tolerated during pregnancy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/10/20 alle ore 00:22:00