Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
The neuropsychological basis of addictive behaviour
Autore:
Everitt, BJ; Dickinson, A; Robbins, TW;
Indirizzi:
Univ Cambridge, Dept Expt Psychol, Cambridge CB2 3EB, England Univ Cambridge Cambridge England CB2 3EB hol, Cambridge CB2 3EB, England
Titolo Testata:
BRAIN RESEARCH REVIEWS
fascicolo: 2-3, volume: 36, anno: 2001,
pagine: 129 - 138
SICI:
0165-0173(200110)36:2-3<129:TNBOAB>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
COCAINE-SEEKING BEHAVIOR; NUCLEUS-ACCUMBENS CORE; PAVLOVIAN APPROACH BEHAVIOR; ANTERIOR CINGULATE CORTEX; MEDIAL PREFRONTAL CORTEX; REWARD-RELATED STIMULI; D-AMPHETAMINE; CONDITIONED REINFORCEMENT; MOLECULAR MECHANISMS; BASOLATERAL AMYGDALA;
Keywords:
addiction; reward; conditioning; cocaine; heroin; actions; habit; drug-seeking;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
122
Recensione:
Indirizzi per estratti:
Indirizzo: Everitt, BJ Univ Cambridge, Dept Expt Psychol, Downing St, Cambridge CB2 3EB, England Univ Cambridge Downing St Cambridge England CB2 3EB , England
Citazione:
B.J. Everitt et al., "The neuropsychological basis of addictive behaviour", BRAIN RES R, 36(2-3), 2001, pp. 129-138

Abstract

The argument advanced in this review is that drug addiction can be understood in terms of normal learning and memory systems of the brain which, through the actions of chronically self-administered drugs, are pathologically subverted, thereby leading to the establishment of compulsive drug-seeking habits, strengthened by the motivational impact of drug-associated stimuli and occurring at the expense of other sources of reinforcement. We review data from our studies that have utilized procedures which reveal the variousinfluences of pavlovian stimuli on goal-directed behaviour, namely discriminated approach, pavlovian-to-instrumental transfer and conditioned reinforcement, in order to demonstrate their overlapping and also unique neural bases. These fundamental studies are also reviewed in the context of the neural and psychological mechanisms underlying drug-seeking behaviour that is under the control of drug-associated environmental stimuli. The ways in which such drug-seeking behaviour becomes compulsive and habitual, as well as the propensity for relapse to drug-seeking even after long periods of relapse, are discussed in terms of the aberrant learning set in train by the effects of self-administered drugs on plastic processes in limbic cortical-ventral striatal systems. (C) 2001 Elsevier Science BY All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 07:15:50