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Titolo:
Synthesis and anti-HIV activity of oleanolic acid derivatives
Autore:
Zhu, YM; Shen, JK; Wang, HK; Cosentino, LM; Lee, KH;
Indirizzi:
Univ N Carolina, Sch Pharm, Nat Prod Lab, Chapel Hill, NC 27599 USA Univ NCarolina Chapel Hill NC USA 27599 d Lab, Chapel Hill, NC 27599 USA Biotech Res Labs Inc, Gaithersburg, MD 20877 USA Biotech Res Labs Inc Gaithersburg MD USA 20877 Gaithersburg, MD 20877 USA
Titolo Testata:
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
fascicolo: 24, volume: 11, anno: 2001,
pagine: 3115 - 3118
SICI:
0960-894X(200112)11:24<3115:SAAAOO>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
AIDS AGENTS; BETULIN DERIVATIVES; INHIBITORS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
13
Recensione:
Indirizzi per estratti:
Indirizzo: Lee, KH Univ N Carolina, Sch Pharm, Nat Prod Lab, Chapel Hill, NC 27599 USA Univ N Carolina Chapel Hill NC USA 27599 hapel Hill, NC 27599 USA
Citazione:
Y.M. Zhu et al., "Synthesis and anti-HIV activity of oleanolic acid derivatives", BIOORG MED, 11(24), 2001, pp. 3115-3118

Abstract

Thirteen oleanolic acid derivatives were prepared and evaluated for anti-HIV activity in H9 lymphocytes. Saturating the C-12-C-13 double bond and converting the C-17-carboxyl group to an aminomethyl group led to compounds 13-15 and 19-20. respectively, which showed improved anti-HIV activity. Compound 15 was the most potent derivative with EC50=0.0039 mug/mL and TI = 3570. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 10:13:27