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Titolo:
In vitro degradation of Polyactive (R) 1000PEOT70PBT30 devices
Autore:
Kellomaki, M; Paasimaa, S; Grijpma, DW; Kolppo, K; Tormala, P;
Indirizzi:
Tampere Univ Technol, Inst Biomat, FIN-33101 Tampere, Finland Tampere UnivTechnol Tampere Finland FIN-33101 IN-33101 Tampere, Finland Univ Twente, Fac Chem Technol, Inst Biomed Technol, NL-7500 AE Enschede, Netherlands Univ Twente Enschede Netherlands NL-7500 AE 500 AE Enschede, Netherlands
Titolo Testata:
BIOMATERIALS
fascicolo: 1, volume: 23, anno: 2002,
pagine: 283 - 295
SICI:
0142-9612(200201)23:1<283:IVDOP(>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLY(BUTYLENE TEREPHTHALATE); POLYETHYLENE OXIDE; COMPOSITES; COPOLYMERS;
Keywords:
polyactive (R); processing; in vitro; degradation properties; crystallization;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Kellomaki, M Tampere Univ Technol, Inst Biomat, POB 589, FIN-33101 Tampere, Finland Tampere Univ Technol POB 589 Tampere Finland FIN-33101 nland
Citazione:
M. Kellomaki et al., "In vitro degradation of Polyactive (R) 1000PEOT70PBT30 devices", BIOMATERIAL, 23(1), 2002, pp. 283-295

Abstract

Polyactive (R) 1000PEOT70PBT30 (a segmented block copolymer of poly(ethylene oxide terephtalate)/poly( butylene terephtalate) with 70/30 PEOT/PBT ratio) was processed into three different types of samples: injection molded to rods, hot-pressed to films and to composite membranes made by hot-pressing a tubular mesh Of poly-L,D-lactide 96/4 between two films of Polyactive (R). The molecular weight of Polyactive (R) was not influenced by processing, but gamma -sterilization seemed to increase the weight average molecular weight (M-w). Mechanical properties of the rods and films decreased rapidlyin hydrolytic conditions due to the hydrogel nature of the polymer, swelling and degradation. Mesh reinforcement increased the mechanical properties,but the components separated during soaking. In vitro the molecular weightof the rods and films started to decrease immediately, but the PEOT (or PEO) proportion remained relatively constant for 26 weeks. Macroscopically, all the wet devices remained intact, but fragmented on drying. Microscopically, topographical formations of polymer were found on the surfaces and small sodium-rich spots were precipitated onto and inside the polymer. Thermal measurements showed that polymer consisted of amorphous PEOT segments and both amorphous and crystalline PBT segments. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 12:41:08