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Titolo:
Enhanced osteoblast response to a polymethylmethacrylate-hydroxyapatite composite
Autore:
Moursi, AM; Winnard, AV; Winnard, PL; Lannutti, JJ; Seghi, RR;
Indirizzi:
Ohio State Univ, Coll Dent, Dept Pediat Dent, Columbus, OH 43210 USA Ohio State Univ Columbus OH USA 43210 Pediat Dent, Columbus, OH 43210 USA Ohio State Univ, Coll Engn, Dept Mat Sci, Columbus, OH 43210 USA Ohio State Univ Columbus OH USA 43210 ept Mat Sci, Columbus, OH 43210 USA Ohio State Univ, Coll Dent, Dept Restorat Dent, Columbus, OH 43210 USA Ohio State Univ Columbus OH USA 43210 storat Dent, Columbus, OH 43210 USA
Titolo Testata:
BIOMATERIALS
fascicolo: 1, volume: 23, anno: 2002,
pagine: 133 - 144
SICI:
0142-9612(200201)23:1<133:EORTAP>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
ADHESIVE BONE-CEMENT; IN-VITRO; FIBRONECTIN; DIFFERENTIATION; REPLACEMENT; MECHANISMS; VIVO;
Keywords:
polymethylmethacrylate; hydroxyapatite; bone cement; osteoblasts; osteogenesis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Moursi, AM Ohio State Univ, Coll Dent, Dept Pediat Dent, Columbus, OH 43210 USA Ohio State Univ Columbus OH USA 43210 , Columbus, OH 43210 USA
Citazione:
A.M. Moursi et al., "Enhanced osteoblast response to a polymethylmethacrylate-hydroxyapatite composite", BIOMATERIAL, 23(1), 2002, pp. 133-144

Abstract

Hydroxyapatite (HA)-reinforced polymers have been proposed as a method of improving the biological properties of bone cements and implant materials. For example, bone cements based on polymethylmethacrylate (PMMA) have long been used to secure orthopedic implants to the skeleton. This composite could also be used as a polished coating on other materials or in bulk form, shaped or molded, to custom fit a specific clinical need. However, complications may occur as a result of the limited mechanical and biological properties of PMMA. The purpose of this investigation was to determine whether theincorporation of HA in a PMMA matrix would enhance the biological properties of osteoblast response as compared to PMMA alone. Fetal rat calvarial osteoblasts were plated on discs of PMMA, PMMA/HA, commercially pure titanium(CpTi) and tissue culture polystyrene (control). Osteoblast attachment andday 2 proliferation were similar on all implant materials, whereas, day 8 proliferation on PMMA/HA was significantly higher than on PMMA and similar to CpTi and control. Extracellular matrix production was examined by immunohistochemistry which indicated that osteoblasts cultured on PMMA/HA showed a more distinct networked pattern of organized fibronectin. Histochemical staining of mineralization was examined by confocal microscopy which demonstrated a higher degree of mineralization in nodules formed on PMMA/HA as compared to PMMA. Together, these results indicate that the addition of HA in a PMMA matrix improves osteoblast response as compared to PMMA alone. Therefore, the incorporation of HA into a PMMA matrix may be a useful method to provide PMMA materials with enhanced osteogenic properties. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 20:40:25