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Titolo:
The biocompatibility evaluation of epoxy resin-based root canal sealers invitro
Autore:
Huang, TH; Yang, JJ; Li, H; Kao, CT;
Indirizzi:
Chung Shan Med & Dent Coll, Inst Stomatol, Taichung 402, Taiwan Chung ShanMed & Dent Coll Taichung Taiwan 402 tol, Taichung 402, Taiwan Chung Shan Med & Dent Coll, Dept Dent, Sect 1, Taichung 402, Taiwan Chung Shan Med & Dent Coll Taichung Taiwan 402 t 1, Taichung 402, Taiwan Chung Shan Med & Dent Coll, Inst Toxicol, Sect 1, Taichung 402, Taiwan Chung Shan Med & Dent Coll Taichung Taiwan 402 t 1, Taichung 402, Taiwan
Titolo Testata:
BIOMATERIALS
fascicolo: 1, volume: 23, anno: 2002,
pagine: 77 - 83
SICI:
0142-9612(200201)23:1<77:TBEOER>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELLS IN-VITRO; FILLING MATERIALS; AH PLUS; DENTAL MATERIALS; CYTOTOXICITY; GENOTOXICITY; FORMALDEHYDE; HEPATOCYTES; TOXICITY;
Keywords:
biocompatibility of epoxy resin sealer; MTT assay; alkaline single cell gel electrophoresis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Kao, CT Chung Shan Med & Dent Coll, Inst Stomatol, 620 Shr Jeng Rd, Taichung 402, Taiwan Chung Shan Med & Dent Coll 620 Shr Jeng Rd Taichung Taiwan 402 an
Citazione:
T.H. Huang et al., "The biocompatibility evaluation of epoxy resin-based root canal sealers invitro", BIOMATERIAL, 23(1), 2002, pp. 77-83

Abstract

The cytotoxic and mutagenic effects of epoxy resin-based root canal sealerAH26 and AH-Plus were determined in vitro. Root canal sealers were eluted for 24h in dimethyl sulfoxide (DMSO) and diluted in culture medium. Cytotoxic effects were assessed using the MTT (tetrazolium dye, 3-(4.5-dimethylthiazol-2-yl)-2.5-diphenyltetrazolium bromide, C(18)H(16)N5SBr] assay for mitochondrial enzyme activity and also the cell viability. Genotoxicity assays were assessed using the alkaline single cell gel electrophoresis assay (comet assay) for DNA damage measurement. Result indicated that both the AH26 and AH-Plus sealers exhibited a dose-dependent increase in astrocyte toxic effects. Additionally, dose-dependent astrocyte DNA damage was also noted for both sealers. Therefore, these epoxy resin-based sealers, AH26 and AH-Plus demonstrated both cytotoxicity and genotoxicity in vitro. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 07:25:42