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Titolo:
Preparation of controlled release ophthalmic drops, for glaucoma therapy using thermosensitive poly-N-isopropylacrylamide
Autore:
Hsiue, GH; Hsu, SH; Yang, CC; Lee, SH; Yang, IK;
Indirizzi:
Natl Tsing Hua Univ, Dept Chem Engn, Hsinchu 300, Taiwan Natl Tsing Hua Univ Hsinchu Taiwan 300 pt Chem Engn, Hsinchu 300, Taiwan Natl Chunghsing Univ, Dept Chem Engn, Taichung 402, Taiwan Natl ChunghsingUniv Taichung Taiwan 402 Chem Engn, Taichung 402, Taiwan Tunghai Univ, Dept Chem Engn, Taichung 407, Taiwan Tunghai Univ TaichungTaiwan 407 v, Dept Chem Engn, Taichung 407, Taiwan Taichung Vet Gen Hosp, Dept Ophthalmol, Taichung 407, Taiwan Taichung Vet Gen Hosp Taichung Taiwan 407 hthalmol, Taichung 407, Taiwan
Titolo Testata:
BIOMATERIALS
fascicolo: 2, volume: 23, anno: 2002,
pagine: 457 - 462
SICI:
0142-9612(200201)23:2<457:POCROD>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
PILOCARPINE; DELIVERY; POLY(N-ISOPROPYLACRYLAMIDE); IMMOBILIZATION; HYDROGELS; INSERTS; INVITRO; DRUGS; WATER; GEL;
Keywords:
thermosensitive polymers; poly-N-isopropylacrylamide; controlled release; glaucoma;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Hsiue, GH Natl Tsing Hua Univ, Dept Chem Engn, Hsinchu 300, Taiwan Natl Tsing Hua Univ Hsinchu Taiwan 300 gn, Hsinchu 300, Taiwan
Citazione:
G.H. Hsiue et al., "Preparation of controlled release ophthalmic drops, for glaucoma therapy using thermosensitive poly-N-isopropylacrylamide", BIOMATERIAL, 23(2), 2002, pp. 457-462

Abstract

In this study, controlled release ophthalmic agents for glaucoma therapy were developed based on the thermosensitivity of poly-N-isopropylacrylamide (PNIPAAm). The clear solution of PNIPAAm was known to undergo phase transition when the temperature was raised from the room temperature to about 32 degreesC. The drug was entrapped in the tangled polymer chains or encapsulated within the crosslinked polymer hydrogel at room temperature, and released progressively after topical application (i.e., at a higher temperature). Linear PNIPAAm and crosslinked PNIAAm nanoparticles containing epinephrine were prepared. The drug release rate and cytotoxicity were investigated in vitro. Ophthalmic formulations based on either linear PNIPAAm or the mixture of linear PNIPAAm and crosslinked PNIPAAm nanoparticles were administeredto rabbits and the intraocular pressure (IOP)lowering effect was evaluated. The decreased pressure response of the formulation based on linear PNIPAAm lasted six-fold longer than that of the conventional eye drop. Furthermore, for formulation based on the mixture of linear PNIPAAm and crosslinked nanoparticles, the pressure-lowering effect lasted eight times longer. Theseresults suggest the use of thermosensitive polymer solutions or hydrogels is potential in controlled release antiglaucoma ophthalmic drugs. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 18:54:16