Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Biocompatibility of anionic collagen matrix as scaffold for bone healing
Autore:
Rocha, LB; Goissis, G; Rossi, MA;
Indirizzi:
Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Pathol, BR-14049900 Ribeirao Preto, SP, Brazil Univ Sao Paulo Ribeirao Preto SP Brazil BR-14049900 BCo Preto, SP, Brazil Univ Sao Paulo, Dept Mol Chem & Phys, Inst Chem Sao Carlos, BR-13560250 Sao Carlos, SP, Brazil Univ Sao Paulo Sao Carlos SP Brazil BR-13560250 BC Sao Carlos, SP, Brazil
Titolo Testata:
BIOMATERIALS
fascicolo: 2, volume: 23, anno: 2002,
pagine: 449 - 456
SICI:
0142-9612(200201)23:2<449:BOACMA>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
CALCIFIC DEGENERATION; INJECTABLE COLLAGEN; CLINICAL USE; REPLACEMENT; BIOMATERIAL; GRAFTS; REPAIR;
Keywords:
collagen/therapeutic use; bone substitutes; bone regeneration; osteogenesis; biocompatible materials;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Rocha, LB Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Pathol, Av Bandeirantes 3900,BR-14049900 Ribeirao Preto, SP, Brazil Univ Sao Paulo Av Bandeirantes 3900 Ribeirao Preto SP Brazil BR-14049900 BC
Citazione:
L.B. Rocha et al., "Biocompatibility of anionic collagen matrix as scaffold for bone healing", BIOMATERIAL, 23(2), 2002, pp. 449-456

Abstract

The basic approach to the treatment of bone defects involves the use of scaffolds to favor tissue growth. Although several bioscaffolds have been proposed for this purpose, the search for new and enhanced materials continuesin an attempt to address the drawbacks of the present ones. Modifying current materials can be a fast and cheap way to develop new ones. Among them, type I collagen allows its structure to be modified using relatively simpletechniques. By means of an alkaline treatment, anionic collagen with enhanced piezoelectric properties can be obtained through hydrolysis of carboxyamides groups of asparagine and glutamine residues from collagen in carboxylic. The process applied to a raw source of collagen, bovine pericardium, provided a sponge-like structure, with heterogeneous pore size, and, moreover, the complete removal of interstitial cells. For the evaluation of the biocompatibility of such matrices, they were implanted in surgically created bone defects in rat tibias. Empty defects served as controls. This experimental model allowed a preliminary evaluation of the osteoconductiveness of the matrices. The histological results presented a low inflammatory response and bone formation within a short period of Lime, similar to that of controls. The low cost of production associated to the biocompatibility and osteoconductivity performance make the anionic collagen matrices promising alternatives for bone defects treatment. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 01:19:30