Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
The use of synthetic polymers for delivery of therapeutic antisense oligodeoxynucleotides
Autore:
Chirila, TV; Rakoczy, PE; Garrett, KL; Lou, X; Constable, IJ;
Indirizzi:
Univ Western Australia, Ctr Ophthalmol & Visual Sci, Nedlands, WA 6009, Australia Univ Western Australia Nedlands WA Australia 6009 nds, WA 6009, Australia Univ Western Australia, Lions Eye Inst, Nedlands, WA 6009, Australia Univ Western Australia Nedlands WA Australia 6009 nds, WA 6009, Australia
Titolo Testata:
BIOMATERIALS
fascicolo: 2, volume: 23, anno: 2002,
pagine: 321 - 342
SICI:
0142-9612(200201)23:2<321:TUOSPF>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
CROSS-LINKED POLY(1-VINYL-2-PYRROLIDINONE); VESICULAR STOMATITIS-VIRUS; ELECTROCHEMICALLY DIRECTED COPOLYMERIZATION; POTENTIAL VITREOUS SUBSTITUTES; NONVIRAL GENE-THERAPY; ANTI-SENSE RNA; OLIGONUCLEOTIDE DELIVERY; IN-VITRO; N-(2-HYDROXYPROPYL)METHACRYLAMIDE COPOLYMERS; POLYETHYLENE-GLYCOL;
Keywords:
antisense strategy; antisense oligodeoxynuclides; endocytosis; drug delivery; charged polymers; neutral polymers;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
210
Recensione:
Indirizzi per estratti:
Indirizzo: Chirila, TV Univ Western Australia, Ctr Ophthalmol & Visual Sci, 2 Verdun St, Nedlands, WA 6009, Australia Univ Western Australia 2 Verdun St Nedlands WA Australia 6009
Citazione:
T.V. Chirila et al., "The use of synthetic polymers for delivery of therapeutic antisense oligodeoxynucleotides", BIOMATERIAL, 23(2), 2002, pp. 321-342

Abstract

Developed over the past two decades, the antisense strategy has become a technology of recognised therapeutic potential, and many of the problems raised earlier in its application have been solved to varying extents. However, the adequate delivery of antisense oligodeoxynucleotides to individual cells remains an important and inordinately difficult challenge. Synthetic polymers appeared on this scene in the middle 1980s, and there is a surprisingly large variety used or proposed so far as agents for delivery of oligodeoxynucleotides. After discussing the principles of antisense strategy, certain aspects of the ingestion of macromolecules by cells, and the present Situation of delivery procedures, this article analyses in detail the attempts to use synthetic polymers as carrier matrices and/or cell membrane permeabilisation agents for delivery of antisense oligodeoxynucleotides. Structural aspects of various polymers, as well as the results, promises and limitations of their use are critically evaluated. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/05/20 alle ore 15:14:56