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Titolo:
Effect of clozapine, haloperidol, or M100907 on phencyclidine-activated glutamate efflux in the prefrontal cortex
Autore:
Adams, BW; Moghaddam, B;
Indirizzi:
Yale Univ, Sch Med, VA Med Ctr, Dept Psychiat, West Haven, CT 06516 USA Yale Univ West Haven CT USA 06516 Dept Psychiat, West Haven, CT 06516 USA
Titolo Testata:
BIOLOGICAL PSYCHIATRY
fascicolo: 10, volume: 50, anno: 2001,
pagine: 750 - 757
SICI:
0006-3223(20011115)50:10<750:EOCHOM>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMINO-ACID RECEPTORS; NONCOMPETITIVE NMDA ANTAGONIST; INDUCED HYPERLOCOMOTION; PREPULSE INHIBITION; DOPAMINE RELEASE; SOCIAL-BEHAVIOR; THERAPEUTIC IMPLICATIONS; ANTIPSYCHOTIC-DRUGS; HEALTHY-VOLUNTEERS; LOCOMOTOR-ACTIVITY;
Keywords:
schizophrenia; antipsychotic drugs; serotonin; ketamine; microdialysis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
59
Recensione:
Indirizzi per estratti:
Indirizzo: Moghaddam, B Yale Univ, Sch Med, VA Med Ctr, Dept Psychiat, 116A-2, West Haven, CT 06516 USA Yale Univ 116A-2 West Haven CT USA 06516 Haven, CT 06516 USA
Citazione:
B.W. Adams e B. Moghaddam, "Effect of clozapine, haloperidol, or M100907 on phencyclidine-activated glutamate efflux in the prefrontal cortex", BIOL PSYCHI, 50(10), 2001, pp. 750-757

Abstract

Background: The increase in glutamate efflux in the prefrontal cortex by the psychotomimetic drugs phencyclidine (PCP) and ketamine may produce the dopaminergic and some of the behavioral effects of these drugs. Here, we examined whether antipsychotic drugs influence this increase. Methods: The effect of haloperidol, clozapine or the 5-HT2A antagonist, M100907, on PCP-induced increase in cortical glutamate efflux was examined by, microdialysis. Because previous studies had suggested that M100907 attenuates some behavioral effects of PCP, we also examined the effect of M100907on PCP-induced cortical and accumbal dopamine activation while making concomitant measures of locomotion and stereotypy. Results: Haloperidol, clozapine or M100907 did not significantly block hyperglutamatergic effects of PCP. M100907 was ineffective in inhibiting the dopaminergic and motoric effects of PCP. Conclusions: These results contrast previous findings with glutamatergic drugs, such as AMPA antagonists or group II metabotropic glutamate agonists,that blocked glutamatergic and motoric effects of PCP. Thus, the PCP glutamate activation model lacks predictive validity, for conventional antipsychotics; however, this model may, be useful for design of novel classes of drugs that target those symptoms of schizophrenia that are not generally, treated with monoamine-based antipsychotics. (C) 2001 Society of Biological Psychiatry.

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Documento generato il 20/01/20 alle ore 04:53:55