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Titolo:
Effect of polyacetylenes on the neurite outgrowth of neuronal culture cells and scopolamine-induced memory impairment in mice
Autore:
Yamazaki, M; Hirakura, K; Miyaichi, Y; Imakura, K; Kita, M; Chiba, K; Mohri, T;
Indirizzi:
Hokuriku Univ, Fac Pharm, Dept Biodynam, Kanazawa, Ishikawa 9201181, JapanHokuriku Univ Kanazawa Ishikawa Japan 9201181 wa, Ishikawa 9201181, Japan Tsumura & Co, Tsumura Cent Labs, Ami, Ibaraki 3001155, Japan Tsumura & CoAmi Ibaraki Japan 3001155 Labs, Ami, Ibaraki 3001155, Japan Hokuriku Univ, Fac Pharm, Dept Pharmacognosy, Kanazawa, Ishikawa 9201181, Japan Hokuriku Univ Kanazawa Ishikawa Japan 9201181 wa, Ishikawa 9201181, Japan
Titolo Testata:
BIOLOGICAL & PHARMACEUTICAL BULLETIN
fascicolo: 12, volume: 24, anno: 2001,
pagine: 1434 - 1436
SICI:
0918-6158(200112)24:12<1434:EOPOTN>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
PANAX-GINSENG; CIRSIUM-JAPONICUM; GROWTH-FACTOR; PC12H CELLS; ACETYLENES; CALLUS; ROOTS;
Keywords:
PC12h cell; neuro2a cell; polyacetylene; neurite outgrowth; memory improvement;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Yamazaki, M Hokuriku Univ, Fac Pharm, Dept Biodynam, Kanazawa, Ishikawa 9201181, Japan Hokuriku Univ Kanazawa Ishikawa Japan 9201181 9201181, Japan
Citazione:
M. Yamazaki et al., "Effect of polyacetylenes on the neurite outgrowth of neuronal culture cells and scopolamine-induced memory impairment in mice", BIOL PHAR B, 24(12), 2001, pp. 1434-1436

Abstract

Polyacetylenic alcohols and their linoleates isolated from Panax ginseng C. A. MEYER and Cirsium japonicum DC., of which the lipophilic extracts had been found to affect the neuritogenesis of cultured paraneurons, were demonstrated to have a significant neuritogenic effect on PC12h and Neuro2a cells. Panaxynol and the acetylenic triol in particular were highly efficient at concentrations greater than or equal to2 muM. Panaxynol (20 mg/kg/d, i.p., for 3 d) was confirmed to improve scopolamine-induced memory deficit in mice (Y-maze task). It is suggested that the promotion of neuritogenesis in cultured paraneurons by the addition of panaxynol is related its ability toimprove memory deficits in animals.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/04/20 alle ore 04:08:36