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Titolo:
Transferrin is not involved in the entry of Ga-67 into hepatocytes from regenerating liver of partially hepatectomized rats
Autore:
Abe, S; Hasegawa, S; Nirasawa, M; Sasaki, M; Ohkubo, Y;
Indirizzi:
Tohoku Pharmaceut Univ, Dept Radiopharm, Aoba Ku, Sendai, Miyagi 9818558, Japan Tohoku Pharmaceut Univ Sendai Miyagi Japan 9818558 Miyagi 9818558, Japan
Titolo Testata:
BIOLOGICAL & PHARMACEUTICAL BULLETIN
fascicolo: 12, volume: 24, anno: 2001,
pagine: 1343 - 1346
SICI:
0918-6158(200112)24:12<1343:TINIIT>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR; LOCALIZATION; GALLIUM; BINDING; CELLS;
Keywords:
gallium-67; ferric chloride; partial hepatectomy; hepatocyte; extracellular matrix;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Abe, S Tohoku Pharmaceut Univ, Dept Radiopharm, Aoba Ku, 4-4-1 Komatsushima, Sendai, Miyagi 9818558, Japan Tohoku Pharmaceut Univ 4-4-1 Komatsushima Sendai Miyagi Japan 9818558
Citazione:
S. Abe et al., "Transferrin is not involved in the entry of Ga-67 into hepatocytes from regenerating liver of partially hepatectomized rats", BIOL PHAR B, 24(12), 2001, pp. 1343-1346

Abstract

Ever since the first observation of Ga-67 accumulation in tumors and inflammatory lesions, Ga-67 has been used to detect various tumors and inflammations. The aims of this study were to clarify whether or not transferrin is involved in the uptake of Ga-67 by the regenerating liver after partial hepatectomy. The uptake of Ga-67 by the liver of rats reached a maximum 2 d after partial hepatectomy. In order to inhibit the binding of Ga-67 to transferrin in the blood, FeCl3 was administered 5 min before the injection of Ga-67. The administration of FeCl3 decreased the uptake of Ga-67 by the liverof the partially hepatectomized rats, suggesting that transferrin is involved in the uptake by the liver. However, Ga-67 was taken up only slightly by hepatocytes obtained from the liver of these rats. We conclude that transferrin is involved in the uptake of Ga-67 by the liver tissue of partially hepatectomized rats but is not involved in its entry into the hepatocytes. Only a slight amount of gallium-67 enters the hepatocytes, and may accumulate primarily in the extracellular matrix of the liver tissue of these rats.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 07:35:40