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Titolo:
Novel polymer-DNA hybrid polymeric micelles composed of hydrophobic poly(D,L-lactic-co-glycolic acid) and hydrophilic oligonucleotides
Autore:
Jeong, JH; Park, TG;
Indirizzi:
Korea Adv Inst Sci & Technol, Dept Biol Sci, Taejon 305701, South Korea Korea Adv Inst Sci & Technol Taejon South Korea 305701 5701, South Korea
Titolo Testata:
BIOCONJUGATE CHEMISTRY
fascicolo: 6, volume: 12, anno: 2001,
pagine: 917 - 923
SICI:
1043-1802(200111/12)12:6<917:NPHPMC>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
BLOCK-COPOLYMER MICELLES; MUSCLE CELL-PROLIFERATION; ANTISENSE OLIGODEOXYNUCLEOTIDES; DRUG-DELIVERY; IN-VITRO; INHIBITION; L-ASPARTATE); ACCUMULATION; ADRIAMYCIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Park, TG Korea Adv Inst Sci & Technol, Dept Biol Sci, Taejon 305701, SouthKorea Korea Adv Inst Sci & Technol Taejon South Korea 305701 th Korea
Citazione:
J.H. Jeong e T.G. Park, "Novel polymer-DNA hybrid polymeric micelles composed of hydrophobic poly(D,L-lactic-co-glycolic acid) and hydrophilic oligonucleotides", BIOCONJ CHE, 12(6), 2001, pp. 917-923

Abstract

Biodegradable poly(D,L-lactic-co-glycolic acid) (PLGA) was chemically conjugated to oligonucleotide (ODN) to form an amphiphatic structure which is similar to an A-B type block copolymer. A terminal end of PLGA was activatedand reacted with primary amine-terminated ODN. The ODN/PLGA conjugates self-assembled in aqueous solution to form a micellar structure by serving PLGA segments as a hydrophobic core and ODN segments as a surrounding hydrophilic corona. Critical micelle concentration was determined by a spectroflurometric method. Atomic force microscopic observation revealed that the micelle size was around 80 nm. These micelles could release ODN in a sustained manner by controlled degradation of hydrophobic PLGA chains. Compared to unconjugated ODN, the ODN/PLGA micelles could be more efficiently transported within cells, presumably by endocytosis. This study proposes a potential delivery method of ODN into cells by forming hybrid ODN/PLGA micelles.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 12:07:41