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Titolo:
Cell membrane transport of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in the liver and systemic bioavailability
Autore:
Yang, MC; McLean, AJ; Le Couteur, DG;
Indirizzi:
Univ Sydney, Canberra Hosp, Canberra Clin Sch, Garran, NSW 2065, AustraliaUniv Sydney Garran NSW Australia 2065 in Sch, Garran, NSW 2065, Australia Australian Natl Univ, John Curtin Sch Med Res, Canberra, ACT 0200, Australia Australian Natl Univ Canberra ACT Australia 0200 rra, ACT 0200, Australia
Titolo Testata:
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
fascicolo: 1, volume: 289, anno: 2001,
pagine: 130 - 136
SICI:
0006-291X(20011123)289:1<130:CMTO1(>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
ORGANIC CATION TRANSPORTER; PARKINSONS-DISEASE; SUBSTANTIA-NIGRA; DOPAMINERGIC-NEURONS; RAT-LIVER; METABOLISM; DRUGS; 1-METHYL-4-PHENYLPYRIDINIUM; HEPATOCYTES; PESTICIDES;
Keywords:
MPTP; Parkinson's disease; neurotoxins; pesticides; hepatocytes; membrane transporters; perfused rat liver; multiple indicator dilution;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Yang, MC Canberra Hosp, Dept Geriatr Med, Yamba Dr, Garran, ACT 2605, Australia Canberra Hosp Yamba Dr Garran ACT Australia 2605 2605, Australia
Citazione:
M.C. Yang et al., "Cell membrane transport of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in the liver and systemic bioavailability", BIOC BIOP R, 289(1), 2001, pp. 130-136

Abstract

Modulation of hepatic disposition of MPTP could influence susceptibility to its neurotoxicity. Therefore, we studied hepatocellular transport of MPTPin the perfused rat liver and isolated rat hepatocytes. The perfused liverextensively extracted MPTP. Amiloride and tubocurarine, inhibitors of OCT1, increased MPTP recovery (253 +/- 78 and 283 +/- 64%, respectively) and reduced PSinflux (0.69 +/- 0.36 to 0.27 +/- 0.11, and 0.97 +/- 0.50 to 0.23 +/- 0.05 ml/s/g, respectively). P-glycoprotein inhibitor, daunomycin, and Oatp 1 & 2 inhibitor, rifamycin, had no effect. In isolated hepatocytes, amiloride and tubocurarine increased hepatic uptake of MPTP (23 +/- 12 and 6 +/- 2%, respectively). Daunomycin reduced MPTP uptake by 22 +/- 8% and rifamycin had no effect. Only a small proportion of MPTP is taken up into hepatocytes by transporters; however, modulation of these transport mechanisms will influence systemic bioavailability. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 17:33:42