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Titolo:
Effect of diazepam binding inhibitor (DBI) on the fluid intake, preferenceand the taste reactivity in mice
Autore:
Manabe, Y; Toyoda, T; Kuroda, K; Imaizumi, M; Yamamoto, T; Fushiki, T;
Indirizzi:
Kyoto Univ, Grad Sch Agr, Div Appl Life Sci, Nutr Chem Lab, Kyoto 6068502,Japan Kyoto Univ Kyoto Japan 6068502 e Sci, Nutr Chem Lab, Kyoto 6068502,Japan Osaka Univ, Grad Sch Human Sci, Lab Behav Physiol, Suita, Osaka 5650871, Japan Osaka Univ Suita Osaka Japan 5650871 Physiol, Suita, Osaka 5650871, Japan
Titolo Testata:
BEHAVIOURAL BRAIN RESEARCH
fascicolo: 1-2, volume: 126, anno: 2001,
pagine: 197 - 204
SICI:
0166-4328(20011129)126:1-2<197:EODBI(>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT CEREBROSPINAL-FLUID; DEPRIVED RATS; PALATABILITY; BENZODIAZEPINES; HYPERPHAGIA; STIMULATION; ENHANCEMENT; MIDAZOLAM; VENTRICLE; ALCOHOL;
Keywords:
diazepam binding inhibitor (DBI); aversion; preference; taste; mice; brain;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Fushiki, T Kyoto Univ, Grad Sch Agr, Div Appl Life Sci, Nutr Chem Lab, Kyoto 6068502,Japan Kyoto Univ Kyoto Japan 6068502 Chem Lab, Kyoto 6068502,Japan
Citazione:
Y. Manabe et al., "Effect of diazepam binding inhibitor (DBI) on the fluid intake, preferenceand the taste reactivity in mice", BEH BRA RES, 126(1-2), 2001, pp. 197-204

Abstract

We have reported that a diazepam binding inhibitor (DBI)-like peptide is released by the aversive quinine stimuli 'Chem. Senses 25 (2000) 739'. To determine the effect of DBI on the fluid intake, we injected a DBI peptide fragment into the fourth ventricle in mice, DBI suppressed the intake of 5% sucrose, water and 0.9 mM quinine-HC1 and the preference for 0.05% saccharin. Administration (i.p. ) Of flumazenil, a benzodiazepine receptor antagonist, 20 min before the injection of DBI (i.c.v.) antagonized the suppressive effect of DBI on the intake and the preference for saccharin. We also studied the dose dependency of the effect of DBI on the intake of 5% sucrose. Injection of DBI in excess of 3 mug suppressed the intake of 5% sucrose in mice. Furthermore, injection of DBI (i.c.v.) increased the aversive response to 0.9% NaCl in the taste reactivity in mice. These results suggest that DBIaffect the preference to food. (C) 2001 Elsevier Science B.V. All rights reserved.

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Documento generato il 02/04/20 alle ore 18:56:33