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Titolo:
High levels of estradiol disrupt conditioned place preference learning, stimulus response learning and reference memory but have limited effects on working memory
Autore:
Galea, LAM; Wide, JK; Paine, TA; Holmes, MM; Ormerod, BK; Floresco, SB;
Indirizzi:
Univ British Columbia, Dept Psychol, Vancouver, BC V6T 1Z4, Canada Univ British Columbia Vancouver BC Canada V6T 1Z4 ver, BC V6T 1Z4, Canada
Titolo Testata:
BEHAVIOURAL BRAIN RESEARCH
fascicolo: 1-2, volume: 126, anno: 2001,
pagine: 115 - 126
SICI:
0166-4328(20011129)126:1-2<115:HLOEDC>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
RADIAL-ARM MAZE; STRIATAL DOPAMINE-RECEPTORS; BETA MESSENGER-RNA; ESTROUS-CYCLE; FEMALE RAT; OVARIECTOMIZED RATS; SPATIAL MEMORY; HIPPOCAMPAL-LESIONS; OVARIAN HORMONES; SEX-DIFFERENCES;
Keywords:
estradiol; amygdala; hippocampus; striatum; prefrontal cortex; learning; radial arm maze;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
75
Recensione:
Indirizzi per estratti:
Indirizzo: Galea, LAM Univ British Columbia, Dept Psychol, 2136 W Mall, Vancouver, BCV6T 1Z4, Canada Univ British Columbia 2136 W Mall Vancouver BC Canada V6T 1Z4 a
Citazione:
L.A.M. Galea et al., "High levels of estradiol disrupt conditioned place preference learning, stimulus response learning and reference memory but have limited effects on working memory", BEH BRA RES, 126(1-2), 2001, pp. 115-126

Abstract

The present study investigated the effects of high levels of estradiol in female rats on four different radial arm maze tasks: the hippocampus-dependent spatial working-reference memory task; the prefrontal cortex- hippocampus dependent delayed win-shift task; the striatum-dependent cued win-stay task; and the amygdala-dependent conditioned place preference task. Ovariectomized female rats were injected daily with either 10 mug of estradiol benzoate or sesame oil vehicle similar to 4 h prior to testing. In Experiment 1, treatment with estradiol disrupted learning on the spatial working-reference memory task by increasing the number of reference memory errors to reach criterion. In Experiment 2, treatment with estradiol had no significant effect on the delayed win-shift task. In Experiment 3, treatment with estradiol resulted in impaired performance on a striatum-dependent cued win-stay task. In Experiment 4, treatment with estradiol impaired the acquisition ofa conditioned place-preference task. Taken together these findings suggestthat high levels of estradiol inhibit reference memory, stimulus response learning, and amygdala-dependent appetitive conditioning while having little effect on working memory. (C) 2001 Elsevier Science B.V. All rights reserved.

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Documento generato il 25/01/20 alle ore 07:05:19