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Titolo:
Neuromodulatory control of interacting medial temporal lobe and neocortex in memory consolidation and working memory
Autore:
Cartling, B;
Indirizzi:
Royal Inst Technol, Dept Theoret Phys, SE-10044 Stockholm, Sweden Royal Inst Technol Stockholm Sweden SE-10044 SE-10044 Stockholm, Sweden
Titolo Testata:
BEHAVIOURAL BRAIN RESEARCH
fascicolo: 1-2, volume: 126, anno: 2001,
pagine: 65 - 80
SICI:
0166-4328(20011129)126:1-2<65:NCOIMT>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
CAT VISUAL-CORTEX; OSCILLATORY NEURONAL RESPONSES; HIPPOCAMPAL THETA RHYTHM; BASAL FOREBRAIN LESIONS; LONG-TERM POTENTIATION; SYNAPTIC TRANSMISSION; CHOLINERGIC SUPPRESSION; ASSOCIATIVE PROCESSES; CORTICAL ACTIVATION; FEATURE-INTEGRATION;
Keywords:
medial temporal lobe; neocortex; memory consolidation; working memory; synaptic plasticity; neuronal adaptation; neuromodulation;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
140
Recensione:
Indirizzi per estratti:
Indirizzo: Cartling, B Royal Inst Technol, Dept Theoret Phys, SE-10044 Stockholm, Sweden Royal Inst Technol Stockholm Sweden SE-10044 ockholm, Sweden
Citazione:
B. Cartling, "Neuromodulatory control of interacting medial temporal lobe and neocortex in memory consolidation and working memory", BEH BRA RES, 126(1-2), 2001, pp. 65-80

Abstract

A model of the interacting medial temporal lobe and neocortical association areas is formulated and applied to memory consolidation and working memory. A simplified connectivity in terms of superassemblies and assemblies of neurons representing types and values, respectively, of object features is underlying the model. Realistic low-dimensional model neurons, developed inparticular to take neuronal adaptation into account, are employed. Observed short- and long-term potentiation and depression of plastic synaptic couplings are incorporated. It is shown that memory consolidation by long-term potentiation, based on repeated activations of neocortical patterns, may beguided by neuromodulated dynamics of the medial temporal lobe via short-term couplings acting as pointers. Bifurcations, i.e. transitions between different modes of network dynamics, with respect to developing synaptic couplings are shown to depend on the adaptivity of excitatory neurons in the medial temporal lobe and thus to be under neuromodulatory control. At weak adaptivity, after an initial temporal segmentation of several objects accounting for the capacity of working memory to resolve several items, attention is selectively focused on a single object according to the model. At intermediate adaptivity, reactivations may persist and long-term synaptic couplings gradually develop. At strong adaptivity, the model predicts attention andmemory consolidation to be subsequently terminated. The neuromodulatory control of the interacting medial temporal lobe and neocortical system via the adaptivity of excitatory neurons may account for several observations on the influence of neuromodulators on various cognitive processes and brain disorders. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 12:42:35