Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Gender-dependent differences in latent inhibition following prenatal stress and corticosterone administration
Autore:
Shalev, U; Weiner, I;
Indirizzi:
Tel Aviv Univ, IL-69978 Tel Aviv, Israel Tel Aviv Univ Tel Aviv Israel IL-69978 v Univ, IL-69978 Tel Aviv, Israel
Titolo Testata:
BEHAVIOURAL BRAIN RESEARCH
fascicolo: 1-2, volume: 126, anno: 2001,
pagine: 57 - 63
SICI:
0166-4328(20011129)126:1-2<57:GDILIF>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
PITUITARY-ADRENAL RESPONSES; ADULT-RATS; NUCLEUS-ACCUMBENS; SWITCHING MODEL; SEX-DIFFERENCES; NORWAY RATS; SCHIZOPHRENIA; ALTERS; RECEPTORS; EXPOSURE;
Keywords:
corticosterone; environmental manipulations; footshock; latent inhibition; prenatal stress; restraint; schizophrenia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
55
Recensione:
Indirizzi per estratti:
Indirizzo: Shalev, U NIDA, Behav Neurosci Sect, IRP, NIH, 5500 Nathan Shock Dr, Baltimore, MD 21224 USA NIDA 5500 Nathan Shock Dr Baltimore MD USA 21224 e, MD 21224 USA
Citazione:
U. Shalev e I. Weiner, "Gender-dependent differences in latent inhibition following prenatal stress and corticosterone administration", BEH BRA RES, 126(1-2), 2001, pp. 57-63

Abstract

Latent inhibition (LI) indexes an organisms' ability to ignore irrelevant stimuli. Its disruption in the rat is considered to provide an animal modelof the impaired ability to ignore irrelevant stimuli in schizophrenia. Given the importance of neurodevelopmental factors in the pathophysiology of schizophrenia, the present experiments investigated the effects of restraint, exposure to inescapable footshock and corticosterone administration during the last trimester of pregnancy, on the development of LI in the adult male and Female offspring. Prenatal restraint had no effect on LI in the adult offspring of both sexes. Inescapable footshock exposure and corticosterone administration led to LI disruption in the male, but not the female offspring. These gender-dependent effects of prenatal treatments on LI suggest that it may provide a neurodevelopmental model of at least a sub-group of schizophrenia, in which environmental factors and gender are considered to play a significant role. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 20:21:20