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Titolo:
Effects of CGS 10746B on hyperactivity and place preference induced by morphine
Autore:
Manzanedo, C; Serrano, A; Aguilar, MA; Rodriguez-Arias, M; Minarro, J;
Indirizzi:
Univ Valencia, Fac Psicol, Area Psicobiol, Valencia 46071, Spain Univ Valencia Valencia Spain 46071 Area Psicobiol, Valencia 46071, Spain
Titolo Testata:
BEHAVIOURAL BRAIN RESEARCH
fascicolo: 1-2, volume: 126, anno: 2001,
pagine: 23 - 32
SICI:
0166-4328(20011129)126:1-2<23:EOC1OH>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
MESOLIMBIC DOPAMINE SYSTEM; INDUCED LOCOMOTOR-ACTIVITY; NON-PSYCHOSTIMULANT DRUGS; D-2 RECEPTOR ANTAGONISTS; DELTA-OPIOID RECEPTORS; RAT NUCLEUS-ACCUMBENS; 6-OHDA LESIONS; INTRAVENOUS COCAINE; RELEASE INHIBITOR; SELF-STIMULATION;
Keywords:
morphine; CGS 10746B; motor activity; CPP;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
62
Recensione:
Indirizzi per estratti:
Indirizzo: Minarro, J Univ Valencia, Fac Psicol, Area Psicobiol, Aptdo 22109, Valencia 46071, Spain Univ Valencia Aptdo 22109 Valencia Spain 46071 ia 46071, Spain
Citazione:
C. Manzanedo et al., "Effects of CGS 10746B on hyperactivity and place preference induced by morphine", BEH BRA RES, 126(1-2), 2001, pp. 23-32

Abstract

The effects of CGS 10746B, a dopamine release inhibitor, on spontaneous locomotor activity, morphine-induced hyperactivity, acquisition of conditioned place paradigm and morphine-induced conditioned place preference (CPP) was evaluated in male mice, In experiment 1, animals treated with CGS 10746B (0.5, 1, 2, 4, 8, 16, 24 and 32 mg/kg), morphine (40 mg/kg) or morphine (40mg/kg) plus CGS 10746B (0.5, 1, 2, 4, 8, 16, 24 and 32 mg/kg) were placed in an actimeter during a period of 90 min, In experiment 2, animals treatedwith CGS 10746B (0.5, 1, 3 and 10 mg/kg), morphine (40 mg/kg) or morphine (40 mg/kg) plus CGS 10746B (0.5, 1, 3 and 10 mg/kg) were conditioned following a procedure unbiased in terms of initial spontaneous preference. In experiment 1, it was found that a decrease in spontaneous locomotor activity was produced between 0 and 45 min after administration of 24 and 32 mg/kg ofCGS 10746B. In contrast, morphine induced hyperactivity between 45 and 90 min after administration. CGS 10746B reduced morphine-induced hyperactivitywith doses of 2 mg/kg and higher. In experiment 2, CGS 10746B did not produce any effect on place conditioning but blocked morphine-induced CPP with doses from 1 mg/kg upwards. Our results confirm that an intact dopamine neurotransmission is critical for the manifestation of the motor and place preference conditioning effects of morphine. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 21:44:20