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Titolo:
Expression of cholesteryl ester transfer protein in human atherosclerotic lesions and its implication in reverse cholesterol transport
Autore:
Zhang, ZY; Yamashita, S; Hirano, K; Nakagawa-Toyama, Y; Matsuyama, A; Nishida, M; Sakai, N; Fukasawa, M; Arai, H; Miyagawa, J; Matsuzawa, Y;
Indirizzi:
Osaka Univ, Grad Sch Med B5, Dept Internal Med & Mol Sci, Suita, Osaka 5650871, Japan Osaka Univ Suita Osaka Japan 5650871 Mol Sci, Suita, Osaka 5650871, Japan Univ Tokyo, Grad Sch Pharmaceut Sci, Dept Hlth Chem, Bunkyo Ku, Tokyo 1130033, Japan Univ Tokyo Tokyo Japan 1130033 lth Chem, Bunkyo Ku, Tokyo 1130033, Japan
Titolo Testata:
ATHEROSCLEROSIS
fascicolo: 1, volume: 159, anno: 2001,
pagine: 67 - 75
SICI:
0021-9150(200111)159:1<67:EOCETP>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIGH-DENSITY-LIPOPROTEINS; MONOCYTE-DERIVED MACROPHAGES; SCAVENGER RECEPTOR; TANGIER-DISEASE; SR-BI; DEFICIENCY; MUTATION; GENE; EFFLUX; CELLS;
Keywords:
atherosclerosis; CETP; CETP deficiency; cholesterol efflux; macrophages; reverse cholesterol transport;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Yamashita, S Osaka Univ, Grad Sch Med B5, Dept Internal Med & Mol Sci, 2-2Yamadaoka, Suita, Osaka 5650871, Japan Osaka Univ 2-2 Yamadaoka Suita Osaka Japan 5650871 871, Japan
Citazione:
Z.Y. Zhang et al., "Expression of cholesteryl ester transfer protein in human atherosclerotic lesions and its implication in reverse cholesterol transport", ATHEROSCLER, 159(1), 2001, pp. 67-75

Abstract

Reverse cholesterol transport (RCT) is the major protective system againstatherosclerosis. In this system, cholesteryl ester transfer protein (CETP)is known to facilitate the transfer of neutral lipids between lipoproteinsin plasma. We reported the pathophysiological significance of CETP by clinical studies with genetic CETP deficiency, showing that this protein plays a crucial role in the RCT system. However, information about the expressionof this protein in the initial step of RCT, macrophages (M() in the blood vessels, is still very limited. In the present study, we have performed immunohistochemical analyses on the expression of CETP in human atherosclerotic lesions. The immunoreactive mass of CETP was abundantly detected in foam cells in human aortic and coronary atherosclerotic lesions, but not in the normal arterial wall. A double immunostaining showed that the majority of CETP-positive foam cells were derived from M) and a minor population appeared to derive from smooth muscle cells. Transient transfection of CETP cDNA into COS-7 cells showed that high density lipoprotein (HDL)-mediated efflux of free cholesterol from the cells expressing CETP was much higher than that from mock-transfected cells, while uptake of HDL-lipids was not affected in cells transfected with CETP cDNA. Efflux of free cholesterol from the Nlobtained from CETP deficiency was significantly decreased compared with that from normal subjects. These data indicate that CETP is expressed in M inthe atherosclerotic lesions and may possess an anti-atherogenic function to remove cholesterol from the cells, suggesting another role of CETP at theinitial step of RCT. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 07:12:16