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Titolo:
A triglyceride-rich fat emulsion and free fatty acids but not very low density lipoproteins impair endothelium-dependent vasorelaxation
Autore:
Lundman, P; Tornvall, P; Nilsson, L; Pernow, J;
Indirizzi:
Karolinska Hosp, Dept Cardiol, SE-17176 Stockholm, Sweden Karolinska HospStockholm Sweden SE-17176 ol, SE-17176 Stockholm, Sweden Karolinska Hosp, King Gustaf V Res Inst, Atherosclerosis Res Unit, SE-17176 Stockholm, Sweden Karolinska Hosp Stockholm Sweden SE-17176 it, SE-17176 Stockholm, Sweden Danderyd Hosp, Div Med, Stockholm, Sweden Danderyd Hosp Stockholm Sweden anderyd Hosp, Div Med, Stockholm, Sweden
Titolo Testata:
ATHEROSCLEROSIS
fascicolo: 1, volume: 159, anno: 2001,
pagine: 35 - 41
SICI:
0021-9150(200111)159:1<35:ATFEAF>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY HEART-DISEASE; VASCULAR REACTIVITY; DIABETES-MELLITUS; BRACHIAL-ARTERY; RISK-FACTORS; VASODILATION; HYPERTRIGLYCERIDEMIA; ATHEROSCLEROSIS; HYPERTENSION; DYSFUNCTION;
Keywords:
antioxidants; endothelial function; free fatty acids; lipoproteins; triglycerides; vasorelaxation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Lundman, P Karolinska Hosp, Dept Cardiol, SE-17176 Stockholm, Sweden Karolinska Hosp Stockholm Sweden SE-17176 6 Stockholm, Sweden
Citazione:
P. Lundman et al., "A triglyceride-rich fat emulsion and free fatty acids but not very low density lipoproteins impair endothelium-dependent vasorelaxation", ATHEROSCLER, 159(1), 2001, pp. 35-41

Abstract

Objective: To investigate the effects of triglycerides and free fatty acids on endothelium-dependent and endothelium-independent vasorelaxation. Methods: Femoral arterial rings from rats were studied in organ baths. The vascular segments were constricted with phenylephrine after 20 min of preincubation with the triglyceride-rich fat emulsion Intralipid (R), free fatty acids (16:0, 18:1, 18:3) bound to bovine serum albumin, or very low density lipoproteins. Endothelium-dependent and endothelium-independent relaxations were determined after administration of acetylcholine and nitric oxide donors, respectively. Results: Preincubation with Intralipid (R) caused a concentration-dependent impairment of endothelium-dependent but not endothelium-independent relaxation, Very low density lipoproteins did not affect vascular function. All free fatty acids impaired endothelium-dependent relaxation,whereas endothelium-independent relaxation was unaffected. Administration of the antioxidant vitamin C partly reversed the impairment of the endothelium-dependent relaxation induced by Intralipid (R) and free fatty acids. Conclusions: The present study demonstrates that the triglyceride-rich fat emulsion Intralipid (R) and individual FFAs impair endothelium-dependent relaxation of arterial rings from rat, whereas triglycerides in the form of VLDL do not affect endothelial function. The finding that the antioxidant vitamin C partly reverses this impairment indicates the involvement of oxidative mechanisms. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 12:16:53