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Titolo:
HMG-CoA reductase inhibitors reduce vascular monocyte chemotactic protein-1 expression in early lesions from hypercholesterolemic swine independentlyof their effect on plasma cholesterol levels
Autore:
Martinez-Gonzalez, J; Alfon, J; Berrozpe, M; Badimon, L;
Indirizzi:
UAB, Hosp Santa Creu & St Pau, Inst Recerca, CSIC,IIBB,Cardiovasc Res Ctr,Barcelona 08025, Spain UAB Barcelona Spain 08025 IIBB,Cardiovasc Res Ctr,Barcelona 08025, Spain
Titolo Testata:
ATHEROSCLEROSIS
fascicolo: 1, volume: 159, anno: 2001,
pagine: 27 - 33
SICI:
0021-9150(200111)159:1<27:HRIRVM>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
SMOOTH-MUSCLE CELLS; NITRIC-OXIDE-SYNTHASE; HUMAN ENDOTHELIAL-CELLS; CHEMOATTRACTANT PROTEIN-1; ATHEROSCLEROTIC LESIONS; MEVALONATE PATHWAY; MONONUCLEAR-CELLS; RABBIT MODEL; IN-VITRO; ATORVASTATIN;
Keywords:
HMG-CoA reductase inhibitors; MCP-1; NOSII; porcine model; vessel wall;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Badimon, L UAB, Hosp Santa Creu & St Pau, Inst Recerca, CSIC,IIBB,Cardiovasc Res Ctr,Avda St Antonio Maria Claret 167, Barcelona 08025, Spain UAB Avda St Antonio Maria Claret 167 Barcelona Spain 08025 ain
Citazione:
J. Martinez-Gonzalez et al., "HMG-CoA reductase inhibitors reduce vascular monocyte chemotactic protein-1 expression in early lesions from hypercholesterolemic swine independentlyof their effect on plasma cholesterol levels", ATHEROSCLER, 159(1), 2001, pp. 27-33

Abstract

Inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase are widely used in the treatment of dyslipemias and have shown beneficial effects in primary and secondary prevention of cardiovascular diseases. There is new information that seems to suggest that the beneficial effects observed may notbe solely attributable to plasma cholesterol reduction. Our objective has been to evaluate the effect of two statins at similar dose, although unequivalent plasma lipid lowering potential, on vessel wall expression of two proteins involved in atherosclerotic lesion progression. We have studied the effects of treatment on vessel wall expression of monocyte chemotactic protein-1 (MCP-1) and the inducible form of nitric oxide synthase (NOS II). Atherosclerosis was induced in pigs by feeding a high cholesterol and saturated fatty acid diet for 50 days. Mild atherosclerotic lesions were found at this early stage of induction. Animals were simultaneously treated with atorvastatin (3 mg/kg/day), pravastatin (3 mg/kg/day) or placebo. Non-HDL-cholesterol levels induced by diet were reduced in the atorvastatin-treated group (63 +/- 8%, P = 0.03) and not as much in the pravastatin treated group (44 +/- 3, P = 0.08). The average MCP-1 expression in carotid, femoral and thoracic aorta was significantly reduced with both statins by 37% (P < 0.05),while NOS II expression was unaffected. Therefore, vascular MCP-I expression was downregulated by statins regardless of their lipid lowering potential and lipo/hydrophilic characteristics. Early downregulation of MCP-1 couldattenuate the inflammation within the vascular wall and prevent the development of atherosclerotic lesions. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/07/20 alle ore 05:50:12