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Titolo:
Dietary hematein ameliorates fatty streak lesions in the rabbit by the possible mechanism of reducing VCAM-1 and MCP-1 expression
Autore:
Oh, GT; Choi, JH; Hong, JJ; Kim, DY; Lee, SB; Kim, JR; Lee, CH; Hyun, BH; Oh, SR; Bok, SH; Jeong, TS;
Indirizzi:
Korea Res Inst Biosci & Biotechnol, Cardiovasc Res Lab, Taejon 305600, South Korea Korea Res Inst Biosci & Biotechnol Taejon South Korea 305600 South Korea Korea Res Inst Biosci & Biotechnol, Immunomodular Res Lab, Taejon 305600, South Korea Korea Res Inst Biosci & Biotechnol Taejon South Korea 305600 South Korea
Titolo Testata:
ATHEROSCLEROSIS
fascicolo: 1, volume: 159, anno: 2001,
pagine: 17 - 26
SICI:
0021-9150(200111)159:1<17:DHAFSL>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL-ADHESION MOLECULE-1; LOW-DENSITY-LIPOPROTEIN; HERITABLE HYPERLIPIDEMIC RABBIT; INFLAMMATORY GENE INDUCTION; VASCULAR ENDOTHELIAL-CELLS; NF-KAPPA-B; E-SELECTIN; ANTIOXIDANTS INHIBIT; AORTIC ENDOTHELIUM; OXIDATIVE STRESS;
Keywords:
hematein; atherosclerosis; MCP-1; VCAM-1;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Jeong, TS Korea Res Inst Biosci & Biotechnol, Cardiovasc Res Lab, Yusong POB 115, Taejon 305600, South Korea Korea Res Inst Biosci & Biotechnol Yusong POB 115 Taejon South Korea 305600
Citazione:
G.T. Oh et al., "Dietary hematein ameliorates fatty streak lesions in the rabbit by the possible mechanism of reducing VCAM-1 and MCP-1 expression", ATHEROSCLER, 159(1), 2001, pp. 17-26

Abstract

Hematein is a compound isolated from Caesalpinia sappan that has been usedin oriental medicine as both an analgesic and an anti-inflammatory agent. In this study, we examined the anti-atherogenic potential of hematein usingcholesterol-fed New Zealand White (NZ)V) rabbits. NZW rabbits were dividedinto a hematein-supplemented (0.05% in diet) group (n = 6), a probucol-supplemented (0.25% in diet) group (n = 6), and a control group (n = 6). After8 weeks of treatments, the extent of the atherosclerotic lesions was significantly reduced in the hematein- supplemented group and the probucol-supplemented group without changing plasma lipoprotein levels. Hematein and probucol prevented the up-regulation of the vascular cell adhesion molecule-1 (VCAM- 1) expression on the descending aorta induced by cholesterol diet. Inculture, hematein also significantly inhibited the secretion of soluble VCAM-1 and of 1-nonocyte chemotactic protein-1 (MCP-1) respectively induced by tumor necrotic factor alpha (TNF-alpha) and mildly oxidized low density lipoprotein in human umbilical vein endothelial cell (HUVEC) culture. Also, hematein inhibited monocyte adhesion to endothelial cell and the activationof NF-kappaB in HUVECs stimulated with TNF-alpha. The results of the present study suggest that the anti-atherogenic effect of hematein is not related to control of the plasma lipid profile but probably related to the inhibition of VCAM-1 and MCP-1 expression resulting in an amelioration of lesion development in the rabbit. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 15:16:23