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Titolo:
The polycyclic musk 7-acetyl-1,1,3,4,4,6-hexamethyl-1,2,3,4-tetrahydronaphthaline lacks liver tumor initiating and promoting activity in rats exposedto human-relevant doses
Autore:
Steinberg, P; Zschaler, I; Thom, E; Kuna, M; Wust, G; Schafer-Schwebel, A; Weisse, G; Kramer, PJ; Weie, G;
Indirizzi:
Univ Potsdam, Inst Ernahrungswissensch, Lehrstuhl Ernahrungstoxikol, D-14558 Bergholz Rehbrucke, Germany Univ Potsdam Bergholz Rehbrucke Germany D-14558 gholz Rehbrucke, Germany Deutsch Inst Ernahrungsforsch, Max Rubner Lab, D-14558 Bergholz Rehbrucke,Germany Deutsch Inst Ernahrungsforsch Bergholz Rehbrucke Germany D-14558 Germany E Merck KGaA, Inst Toxikol, D-64271 Darmstadt, Germany E Merck KGaA Darmstadt Germany D-64271 xikol, D-64271 Darmstadt, Germany
Titolo Testata:
ARCHIVES OF TOXICOLOGY
fascicolo: 9, volume: 75, anno: 2001,
pagine: 562 - 568
SICI:
0340-5761(200111)75:9<562:TPM7>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLUTATHIONE S-TRANSFERASE; HUMAN ADIPOSE-TISSUE; GST-P; CHEMICAL HEPATOCARCINOGENESIS; PRENEOPLASTIC CELLS; FRAGRANCES; FOCI; INDUCTION; ENZYME; MARKER;
Keywords:
7-Acetyl-1,1,3,4,4,6-hexamethyl-1,2,3,4-tetrahydronaphthaline; hepatotoxicity; liver tumor initiation; liver tumor promotion;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Steinberg, P Univ Potsdam, Inst Ernahrungswissensch, Lehrstuhl Ernahrungstoxikol, Arthur Scheunert Allee 114-116, D-14558 Bergholz Rehbrucke, GermanyUniv Potsdam Arthur Scheunert Allee 114-116 Bergholz Rehbrucke Germany D-14558
Citazione:
P. Steinberg et al., "The polycyclic musk 7-acetyl-1,1,3,4,4,6-hexamethyl-1,2,3,4-tetrahydronaphthaline lacks liver tumor initiating and promoting activity in rats exposedto human-relevant doses", ARCH TOXIC, 75(9), 2001, pp. 562-568

Abstract

7-Acetyl-1,1,3,4,4,6-hexamethyl-1.2.3,4-tetrahydronaphthaline (AHTN) is one of the two most widely used fragrances of a group of substances known collectively as the polycyclic musks. In the last few years evidence has been accumulating that AHTN is hepatotoxic when administered at high doses. In the present study the subchronic hepatotoxicity of AHTN administered to ratsat doses within the human exposure range was evaluated. For this purpose female and male juvenile Wistar rats were exposed to AHTN (300 mug/kg body weight per day, i.p.) alone or to a single dose of diethylnitrosamine (DEN) (100 mg/kg body weight, i.p.) followed by AHTN ( 1, 10, 100 or 300 mug; kg body weight per day, i.p.) for 90 days. Thereafter the liver architecture as well as the presence of placental glutathione S-transferase (GST-P)-positive hepatic lesions was assessed. In male animals receiving AHTN alone or in combination with DEN the number of GST-P-positive single hepatocytes was similar to that in untreated rats, while GST-P-positive mini-foci and foci were not observed. In the case of female rats the number of GSTP-positive single hepatocytes and mini-foci in AHTN- treated rats was similar to that in untreated animals, whereas in those animals receiving AHTN either alone or in combination with DEN, GST-P-positive foci could not be detected or were present in a number as similar to that in untreated rats. In conclusion, in the present study it has been shown that AHTN administered over a 90-dayperiod in concentrations similar to those taken up daily by humans does not lead to hepatotoxicity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 16:57:22