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Titolo:
Bioavailability of cadmium from infant diets in newborn rats
Autore:
Eklund, G; Grawe, KP; Oskarsson, A;
Indirizzi:
Swedish Univ Agr Sci, Dept Pharmacol & Toxicol, S-75123 Uppsala, Sweden Swedish Univ Agr Sci Uppsala Sweden S-75123 col, S-75123 Uppsala, Sweden Natl Food Adm Toxicol Lab, Div Toxicol, S-75126 Uppsala, Sweden Natl Food Adm Toxicol Lab Uppsala Sweden S-75126 S-75126 Uppsala, Sweden
Titolo Testata:
ARCHIVES OF TOXICOLOGY
fascicolo: 9, volume: 75, anno: 2001,
pagine: 522 - 530
SICI:
0340-5761(200111)75:9<522:BOCFID>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTESTINAL-ABSORPTION; GASTROINTESTINAL ABSORPTION; CASEIN PHOSPHOPEPTIDES; WHEAT BRAN; HUMAN-MILK; COWS MILK; MICE; FORMULAS; EXPOSURE; CALCIUM;
Keywords:
absorption; cadmium; infant formula; newborn;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Eklund, G Swedish Univ Agr Sci, Dept Pharmacol & Toxicol, BMC,POB 573, S-75123 Uppsala, Sweden Swedish Univ Agr Sci BMC,POB 573 Uppsala Sweden S-75123 Sweden
Citazione:
G. Eklund et al., "Bioavailability of cadmium from infant diets in newborn rats", ARCH TOXIC, 75(9), 2001, pp. 522-530

Abstract

Infants are exposed to higher levels of cadmium (Cd) from infant and follow-on formulas than from breast milk. We studied the bioavailability of (CdCl2)-Cd-109 from cows' milk formula, soy formula, wheat,oat milk formula, wholemeal/milk formula and water in 11-day-old rat pups. The pups received a single oral dose of one diet labelled with Cd-109, 0.1 or 0.3 mg Cd/kg bodyweight. After 2 or 24 h or 4.9 or 12 days the fractional retention of Cd-109 in the whole body, in segments of rinsed small intestine and in tissue was measured in a gamma counter. Pups receiving Cd-109 in wetter or cows' milk formula had the highest mean whole-body retention. It ranged from 67% ofthe dose in the water group to 52% in the wholemeal/milk formula group 4 days after dosing. The retention of Cd-109 in the rinsed small intestine wassignificantly higher in the water group and the cows' milk formula group than in the cereal-based formula groups at 24 h and 4 days after dosing. It was still high in all groups on day 9. ranging from 26 to 11%. Initially most of the Cd-109 was retained in the duodenum but by day 4 it had moved further down into the jejunum. In the liver, the highest and lowest retention oil day 4 was 16 parts per thousand and 3 parts per thousand of the dose inthe water group and wholemeal, milk formula group, respectively. In the kidney. Cd-109 was still increasing 12 days after exposure in all groups. Whole-body retention and tissue levels were higher than previously reported inadult animals. The lower bioavailability of Cd-109 from the cereal-based formulas compared to water and cows' milk formula on the longer survival times is most likely explained by Cd binding to dietary fibre and phytic acid in the cereal-based formulas reducing the intestinal binding and decreasingthe bioavailability of Cd. The high retention of Cd-109 in the small intestine, leading to a prolonged absorption period, emphasizes the importance of extending studies on neonatal Cd absorption over a long time period in order to detect for example, endpoints, accumulation of Cd in the kidney.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 10:50:11