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Titolo:
Total cholesterol/HDL cholesterol ratio vs LDL cholesterol/HDL cholesterolratio as indices of ischemic heart disease risk in men - The Quebec Cardiovascular Study
Autore:
Lemieux, I; Lamarche, B; Couillard, C; Pascot, A; Cantin, B; Bergeron, J; Dagenais, GR; Despres, JP;
Indirizzi:
Laval Hosp, Quebec Heart Inst, Res Ctr, St Foy, PQ G1V 4G5, Canada Laval Hosp St Foy PQ Canada G1V 4G5 , Res Ctr, St Foy, PQ G1V 4G5, Canada CHUL, Lipid Res Ctr, Res Ctr, St Foy, PQ, Canada CHUL St Foy PQ CanadaCHUL, Lipid Res Ctr, Res Ctr, St Foy, PQ, Canada
Titolo Testata:
ARCHIVES OF INTERNAL MEDICINE
fascicolo: 22, volume: 161, anno: 2001,
pagine: 2685 - 2692
SICI:
0003-9926(200112)161:22<2685:TCCRVL>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
DENSITY LIPOPROTEIN CHOLESTEROL; HDL-CHOLESTEROL; APOLIPOPROTEIN-B; METABOLIC SYNDROME; ABDOMINAL OBESITY; VISCERAL OBESITY; FOLLOW-UP; A-I; PLASMA; MARKER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Despres, JP Laval Hosp, Quebec Heart Inst, Res Ctr, 2725,Chem St Foy,PavilMallet 2nd Floor, St Foy, PQ G1V 4G5, Canada Laval Hosp 2725,Chem St Foy,Pavil Mallet 2nd Floor St Foy PQ Canada G1V 4G5
Citazione:
I. Lemieux et al., "Total cholesterol/HDL cholesterol ratio vs LDL cholesterol/HDL cholesterolratio as indices of ischemic heart disease risk in men - The Quebec Cardiovascular Study", ARCH IN MED, 161(22), 2001, pp. 2685-2692

Abstract

Background: Total cholesterol (TC)/high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C)/HDL-C ratios are usedto predict ischemic heart disease risk. There is, however, no consensus onwhich of these 2 indices is superior. The objective of the present study was to present evidence that the LDL-C/HDL-C ratio may underestimate ischemic heart disease risk in overweight hyperinsulinemic patients with high triglyceride (TG)-low HDL-C dyslipidemia. Methods: A total of 2103 middle-aged men in whom measurements of the metabolic profile were performed in the fasting state were recruited from 7 suburbs of the Quebec metropolitan area. Results: The relationship of LDL-C/HDL-C to TC/HDL-C ratios was examined among men in the Quebec Cardiovascular Study classified into tertiles of fasting TG levels. For any given LDL-C/HDL-C ratio, the TC/HDL-C ratio was higher among men in the top TG tertile (> 168 mg/dL [>1.9 mmol/L]) than in menin the first and second TG tertiles. Adjustment of the TC/HDL-C ratio for LDL-C/HDL-C by covariance analysis generated significant differences in average TC/HDL-C ratios among TG tertiles (P < .001). Greater differences in features of the insulin resistance syndrome (insulinemia, apolipoprotein B, and LDL size) were noted across tertiles of the TC/HDL-C ratio than tertiles of the LDL-C/HDL-C ratio. Conclusion: Variation in the TC/HDL-C ratio may be associated with more substantial alterations in metabolic indices predictive of ischemic heart disease risk and related to the insulin resistance syndrome than variation in the LDL-C/HDL-C ratio.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 01:10:36