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Titolo:
Identification of hydroxylated PCB metabolites and other phenolic halogenated pollutants in human blood plasma
Autore:
Hovander, L; Malmberg, T; Athanasiadou, M; Athanassiadis, L; Rahm, S; Bergman, A; Wehler, EK;
Indirizzi:
Stockholm Univ, Dept Environm Chem, S-10691 Stockholm, Sweden Stockholm Univ Stockholm Sweden S-10691 Chem, S-10691 Stockholm, Sweden
Titolo Testata:
ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY
fascicolo: 1, volume: 42, anno: 2002,
pagine: 105 - 117
SICI:
0090-4341(200201)42:1<105:IOHPMA>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
METHYL SULFONE METABOLITES; HUMAN TRANSTHYRETIN; POLYCHLORINATED-BIPHENYLS; CHLORINATED PHENOLS; TEMPORAL TRENDS; DIPHENYL ETHERS; PREGNANT MICE; OCTACHLOROSTYRENE; ORGANOHALOGENS; CONTAMINANTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
72
Recensione:
Indirizzi per estratti:
Indirizzo: Hovander, L Stockholm Univ, Dept Environm Chem, S-10691 Stockholm, Sweden Stockholm Univ Stockholm Sweden S-10691 91 Stockholm, Sweden
Citazione:
L. Hovander et al., "Identification of hydroxylated PCB metabolites and other phenolic halogenated pollutants in human blood plasma", ARCH ENV C, 42(1), 2002, pp. 105-117

Abstract

A growing number of studies have reported phenolic halogenated compounds (PHCs) that are retained in the blood of humans and wildlife. These PHCs maybe industrial chemicals; metabolites thereof, as in the case with polychlorobiphenylols (OH-PCBs); or of natural origin. The present study was aimed to identify hitherto unknown PHCs in human plasma with chemical structures that are consistent to PHCs known to possess endocrine-disrupting activity. For this purpose, samples of blood plasma from 10 randomly selected male blood donors from Sweden were pooled and analyzed by GC/ECD and GC/MS. Brominated, bromochlorinated, and chlorinated methyl derivatives of phenols and OH-PCBs were synthesized to be used as authentic reference standards. More than 100 PHCs were indicated in the plasma, and among those a total of 9 monocyclic brominated or chlorinated phenol-, guaiacol-, and/or catechol-typecompounds were identified as their methylated derivatives. The two major compounds were 2,4,6-tribromophenol and pentachlorophenol. Thirty-eight OH-PCB congeners were structurally identified on two GC columns of different polarity. The origin of the OH-PCB metabolites in the context of their parentPCB congeners are suggested. Other PHCs identified in the male plasma wereTriclosan (5-chloro-2-[2,4-dichlorophenoxyl] phenol), a common bactericide; 4-hydroxy-heptachlorostyrene, a metabolite of octachlorostyrene; and 3,5-dibromo-2-(2,4-dibromophenoxy)phenol, a natural compound and a potential metabolite of polybrominated diphenyl ethers.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 13:57:31