Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Interactions in developmental toxicology: Effects of concurrent exposure to lead, organic mercury, and arsenic in pregnant mice
Autore:
Belles, M; Albina, ML; Sanchez, DJ; Corbella, J; Domingo, JL;
Indirizzi:
Univ Rovira & Virgili, Sch Med, Lab Toxicol & Environm Hlth, E-43201 Reus,Spain Univ Rovira & Virgili Reus Spain E-43201 vironm Hlth, E-43201 Reus,Spain Univ Barcelona, Sch Med, Toxicol Unit, E-08036 Barcelona, Spain Univ Barcelona Barcelona Spain E-08036 ol Unit, E-08036 Barcelona, Spain
Titolo Testata:
ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY
fascicolo: 1, volume: 42, anno: 2002,
pagine: 93 - 98
SICI:
0090-4341(200201)42:1<93:IIDTEO>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHEMICAL-MIXTURES; PRENATAL DEVELOPMENT; SODIUM ARSENATE; RISK ASSESSMENT; SEA-URCHINS; TOXICITY; TRIOXIDE; TERATOGENICITY; COMBINATIONS; SELENIUM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Domingo, JL Univ Rovira & Virgili, Sch Med, Lab Toxicol & Environm Hlth, San Lorenzo 21, E-43201 Reus, Spain Univ Rovira & Virgili San Lorenzo 21 Reus Spain E-43201 Spain
Citazione:
M. Belles et al., "Interactions in developmental toxicology: Effects of concurrent exposure to lead, organic mercury, and arsenic in pregnant mice", ARCH ENV C, 42(1), 2002, pp. 93-98

Abstract

The development toxicity of lead nitrate (25 mg/kg, SC), methylmercury chloride (12.5 mg/kg, PO), and sodium arsenite (6 mg/kg, SC) was assessed in CD1 mice following administration on gestation day 10 of these chemicals separately or in their binary and ternary combinations. Cesarean sections wereperformed on day 18 of gestation, and fetuses were examined formal formations and variations. Three fetuses from each dam were used for whole-body analyses of Pb, Hg, and As. Maternal toxic effects were more remarkable in the group concurrently exposed to Pb, Hg, and As than in those given binary combinations of the elements. In turn, maternal toxicity was more notable inthese groups than in those given separately the test compounds. With regard to developmental toxicity, the most relevant effects (decreased fetal weight, cleft palate) corresponded to the Hg-treated groups. It is in agreement with the finding that in all experimental groups the levels of Pb and As in whole fetuses were under their respective detection limits. In general terms, the present data suggests that at the current doses, the interactive effects of Pb and As on Hg-induced developmental toxicity were not greater than additive. III contrast, exposure of pregnant mice to Pb and As at doses that were practically nontoxic to dams, concurrently with organic Hg at atoxic dose, caused supra-additive interactions in maternal toxicity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 01:48:15