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Titolo:
Left-right asymmetry determination in vertebrates
Autore:
Mercola, M; Levin, M;
Indirizzi:
Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 ed, Dept Cell Biol, Boston, MA 02115 USA Forsyth Inst, Boston, MA 02115 USA Forsyth Inst Boston MA USA 02115Forsyth Inst, Boston, MA 02115 USA
Titolo Testata:
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY
, volume: 17, anno: 2001,
pagine: 779 - 805
SICI:
1081-0706(2001)17:<779:LADIV>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
LEFT-RIGHT AXIS; GAP JUNCTIONAL COMMUNICATION; LEFT-RIGHT SPECIFICATION; NODAL-RELATED SIGNALS; EARLY XENOPUS EMBRYO; SITUS-INVERSUS; CHICK-EMBRYO; INSERTIONAL MUTATION; MESODERM INDUCTION; PRIMITIVE STREAK;
Keywords:
laterality; TGF beta; Nodal; Shh; cilia; gap junctions; mice; chick; Xenopus;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
147
Recensione:
Indirizzi per estratti:
Indirizzo: Mercola, M Harvard Univ, Sch Med, Dept Cell Biol, 240 Longwood Ave, Boston, MA 02115 USA Harvard Univ 240 Longwood Ave Boston MA USA 02115 MA 02115 USA
Citazione:
M. Mercola e M. Levin, "Left-right asymmetry determination in vertebrates", ANN R C DEV, 17, 2001, pp. 779-805

Abstract

A distinctive and essential feature of the vertebrate body is a pronouncedleft-right asymmetry of internal organs and the central nervous system. Remarkably, the direction of left-right asymmetry is consistent among all normal individuals in a species and, for many organs, is also conserved acrossspecies, despite the normal health of individuals with mirror-image anatomy. The mechanisms that determine stereotypic left-right asymmetry have fascinated biologists for over a century. Only recently, however, has our understanding of the left-right patterning been pushed forward by links to specific genes and proteins. Here we examine the molecular biology of the three principal steps in left-right determination: breaking bilateral symmetry, propagation and reinforcement of pattern, and the translation of pattern into asymmetric organ morphogenesis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 05:53:35