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Titolo:
Peroxisome biogenesis
Autore:
Purdue, PE; Lazarow, PB;
Indirizzi:
Mt Sinai Sch Med, Dept Cell Biol & Anat, New York, NY 10029 USA Mt Sinai Sch Med New York NY USA 10029 iol & Anat, New York, NY 10029 USA
Titolo Testata:
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY
, volume: 17, anno: 2001,
pagine: 701 - 752
SICI:
1081-0706(2001)17:<701:PB>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
MATRIX PROTEIN IMPORT; YEAST HANSENULA-POLYMORPHA; ACYL-COA OXIDASE; RHIZOMELIC CHONDRODYSPLASIA PUNCTATA; UBIQUITIN-CONJUGATING ENZYME; TARGETING SIGNAL-RECEPTOR; RAT-LIVER PEROXISOMES; ALANINE-GLYOXYLATE AMINOTRANSFERASE-1; TETRATRICOPEPTIDE REPEAT-DOMAIN; PRIMARY HYPEROXALURIA TYPE-1;
Keywords:
peroxin; PEX; organelle assembly;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
230
Recensione:
Indirizzi per estratti:
Indirizzo: Purdue, PE Mt Sinai Sch Med, Dept Cell Biol & Anat, New York, NY 10029 USAMt Sinai Sch Med New York NY USA 10029 New York, NY 10029 USA
Citazione:
P.E. Purdue e P.B. Lazarow, "Peroxisome biogenesis", ANN R C DEV, 17, 2001, pp. 701-752

Abstract

Fifteen years ago, we had a model of peroxisome biogenesis that involved growth and division of preexisting peroxisomes. Today, thanks to geneticallytractable model organisms and Chinese hamster ovary cells, 23 PEX genes have been cloned that encode the machinery ("peroxins") required to assemble the organelle. Membrane assembly and maintenance requires three of these (peroxins 3, 16, and 19) and may occur without the import of the matrix (lumen) enzymes. Matrix protein import follows a branched pathway of soluble recycling receptors, with one branch for each class of peroxisome targeting sequence (two are well characterized), and a common trunk for all. At least one of these receptors, Pex5p, enters and exits peroxisomes as it functions. Proliferation of the organelle is regulated by Pex11p. Peroxisome biogenesis is remarkably conserved among eukaryotes. A group of fatal, inherited neuropathologies are recognized as peroxisome biogenesis diseases; the responsible genes are orthologs of yeast or Chinese hamster ovary peroxins. Future studies must address the mechanism by which folded, oligomeric enzymes enter the organelle, how the peroxisome divides, and how it segregates at cell division. Most pex mutants contain largely empty membrane "ghosts" of peroxisomes; a few mutants apparently lacking peroxisomes entirely have led some to propose the de novo formation of the organelle. However, there is evidence for residual peroxisome membrane vesicles ("protoperoxisomes") in some of these, and the preponderance of data supports the continuity of the peroxisome compartment in space and time and between generations of cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 13:27:49